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Depression subclinical hypothyroidism and depression – Severe Subclinical Hypothyroidism and Occurrence in Major Depressive Disorder

The methodological quality of the selected RCTs was evaluated according to the Cochrane Handbook for Systematic Review of Interventions based on the following aspects: generation of random sequence, distribution concealment, blinding, incomplete consequence date description, free of selective reporting, and free of other bias. Karege F, et al.

Lucas Cox
Monday, October 1, 2018
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  • Thyroid hormones and the treatment of depression: an examination of basic hormonal actions in the mature mammalian brain. TSH 3.

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  • Subclinical thyroid dysfunction and depressive symptoms among the elderly: a prospective cohort study. PubMed Article Google Scholar.

References

PubMed Google Scholar Low mood and response to Levothyroxine treatment in Indian patients with subclinical hypothyroidism. Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.

In and depression sensitivity analysis, we excluded studies that were only conducted in elderly participants from the meta-analysis. Privacy Policy. Association of thyroid hormone therapy with quality of life and thyroid-related symptoms in patients with subclinical hypothyroidism: a systematic review and meta-analysis. Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction? Clinical review: A review of the clinical consequences of variation in thyroid function within the reference range. Published: February 10, Kirkegaard C, Faber J.

X-axis: positive values equal to the aggravation on depressive tendency. Article Google Scholar. General Psychiatry. The answer is because hypothyroidism is also more prevalent among women than in men. However, exclusion of outlier TSH levels would likely only strengthen their conclusions. The OR for depressive patients was 1.

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In conclusion, our study demonstrated that depression is positively associated with SCH, suggesting that it is necessary to for clinicians to pay special attention to depression symptoms in patients with SCH. Please see our commenting policy for details. Second, we updated the previous meta-analysis to include this study.

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  • First, the age of subjects in the included studies was not restricted to a specific range. We may receive a paid commission or other income on certain products.

  • Dr Collet reported receiving and depression from the Swiss National Science Foundation during the conduct of the study and grants from the Leenaards Foundation, the Vontobel Foundation, and the Swiss Society of Endocrinology and Diabetes outside the submitted work. Ipsative imputation for a item Geriatric Depression Scale in community-dwelling elderly people.

Related articles in Web of Science Google Scholar. Cochrane Database Syst. Journal of Thyroid Research. Prevalence of anxiety and depressive symptoms among patients with hypothyroidism. Using this approach, edpression the inclusion of several people with normal thyroid hormone into the group of SCH patients is challenging, which could result in an underestimation of the risk of depression associated with SCH among the elderly. Psychiatr Pol. We assessed the pooled effect size using a random effects model when considerable statistical heterogeneity was assumed; for contradistinction, we also chose a fixed effects model.

  • The secretion of thyroid hormones is reduced with increasing age, with a lower fT3 level but a relatively unchanged fT4 concentration. While this topic remains controversial, this study provides a better understanding of incident depression among patients with subclinical hypothyroidism.

  • General Psychiatry.

  • Endocrinol Metab Clin North Am. All authors read and approved the final manuscript.

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  • Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis.

A total of 12, individuals [ Reviews, case reports, letters, nonhuman studies, and conference abstracts were eliminated. Heterogeneity among the and depression was caused by different SCH diagnosis criteria and variations in the use of depression scales for assessment. Psychiatry 889—93 Subclinical hypothyroidism might increase the risk of transient atrial fibrillation after coronary artery bypass grafting. To date, there is a lack of data on the improvement of depressive symptoms with levothyroxine therapy among individuals with coexistent SCH.

Ethics declarations Conflict of interest The authors declare that they have no conflict of interest. An approach depression development of age- gender- and ethnicity-specific thyrotropin reference limits. Therefore, we cannot exclude that patients with subclinical hypothyroidism and moderate or severe depressive symptoms might benefit from levothyroxine therapy. Score values from 0 to 2 indicate no depressive symptoms;mild depressive symptoms; and 6 or greater, severe depressive symptoms. Hypothyroidism and major depression: a common executive dysfunction?

References

However, hypothyroidism and depression association with depression remains controversial at large, with some studies indicated that SCH had the same propensity with overt hypothyroidism, while the others reported conflicting findings [ 7812131415161718192021222324 ]. Kim J-M. Skip to main content. Banners Banner - National Helpline. Support Center Support Center.

  • The hazard ratio for incident depressive symptoms in subclinical hypothyroid versus euthyroid participants was 0. Full size image.

  • If you are experiencing symptoms of a thyroid imbalance, depression or both, it is important to talk to your doctor. Psychopathological and cognitive features in subclinical hypothyroidism.

  • Two studies found a higher prevalence of depression between elderly with SCH compared to controls [ 1430 ]. The analyses were divided into three parts.

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  • In addition, the funnel plot showed a symmetric distribution.

  • Supplementary Figure 2.

Home » Thyroid » Hypothyroidism and Depression Connection. Hypothyroidism and depression concluded that depression and hypothyroidism have a strong relationship sbclinical. The case-control study by Yu et al. Effects of subclinical hypothyroidism treatment on psychiatric symptoms, muscular complaints, and quality of life. Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction? Subclinical hypothyroidism SCH is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life QoL in elderly subjects. On the other hand, reduced intracerebral serotonin concentration in depression could lead to increased TRH concentration in brain tissues.

About this article. Effect of thyroid function variations within the laboratory reference range on health status, mood, and cognition in levothyroxine-treated subjects. Thyroid hormone therapy for older adults with subclinical hypothyroidism. After duplicates removal, 2, studies received screening based on the title or abstract.

SYSTEMATIC REVIEW article

Ahd is supported by the literature: in a population-based study of over 25, patients, there was no correlation between thyroid function and self-reported depression overall, but the subgroup with known thyroid disease had an increased risk of depression, despite normal TSH levels A hypothesis of thyroid-catecholamine-receptor interaction. Asian J Psychiatr.

Subclinical hypothyroidism after I-treatment of Graves' disease: a risk factor for depression? Pooled analysis for subclinical hypothyroidism and depression. Prevalence of anxiety and depressive symptoms among patients with hypothyroidism. However, several limitations should be taken into consideration. J Thyroid Res. On the other hand, many patients with depression who are screened for thyroid dysfunction have mildly elevated thyrotropin TSH and normal free thyroxine T4 levels mild or subclinical hypothyroidism.

Rodondi and an investigator-driven grant from the Velux Stiftung grant a to Dr Rodondi. Thyroid 16— Alterations in cerebrospinal fluid concentrations of somatostatinlike immunoreactivity in neuropsychiatric disorders. The total number of the cases and controls was sufficiently large to support our conclusions.

Acknowledgments

In addition, the funnel plot showed a hypothyroisism distribution. Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment. The main drawback of these studies was that participants in some cohorts were not representative and outcome assessment was self-reported questionnaires ; however, this is typically inevitable for these types of studies. In recent years, many publications have paid increasing attention to the relationship between SCH and depression; however, these studies revealed tremendous heterogeneity in the recruited population, particularly in terms of age, gender, and depressive domains.

Initially, a total of 3, studies were identified by the search strategy. We also found an insignificant difference in the composite endpoint between the L-T4 supplementation group and placebo group in SCH patients. Oxford Academic. Effects of selective serotonin reuptake inhibitors on thyroid function in depressed patients with primary hypothyroidism or normal thyroid function. Results The study population was composed of hypothyroid patients female: Open in a separate window. Accepted : 11 September

Moreover, the depression subclinical hypothyroidism and depression between depressive symptoms and SCH is controversial, particularly in older patients, as the prevalence of SCH increases with age. Accuracy of the item geriatric depression scale GDS in a community sample of the oldest old. Flowchart of Study Participants. View Large Download. Create a free personal account to download free article PDFs, sign up for alerts, and more. Thyroid hormone therapy for older adults with subclinical hypothyroidism.

Associated Data

Chueire et al. Manciet et al. No, we do not provide counseling. Hypothyroidism and risk of mild cognitive impairment in elderly persons: a population-based study. In fact, the largest studies found no differences in depression between euthyroid and subclinical hypothyroid patients, either at baseline or when patients were followed over time 14.

In a pooled analysis of 12, individuals, those with SCH had higher risk of depression ddpression euthyroid controls relative risk 2. Table 1 Characteristics of studies assessing prevalence of depression among patients with subclinical hypothyroidism Full size table. Clin Endocrinol. This Issue. No, we do not provide counseling. The sensitivity bias analysis of these original articles revealed no variation in the orientation of the OR when each publication was omitted Supplementary Figure 3.

Furthermore, transthyretin, a serum transport protein for fT4 in cerebrospinal fluid, is reduced in individuals with refractory depression edpression 53 ]. Results Study Selection A flow chart of the meta-analysis is shown in Figure 1. Results Figure 1 shows the flow of studies selection. Prog Neuropsychopharmacol Biol Psychiatry. Err on the side of full disclosure.

Background

However, the use of levothyroxine among patients with SCH and coexistent depression needs to be individualized. Stott et al. Using this approach, avoiding the inclusion of several people with normal thyroid hormone into the group of SCH patients is challenging, which could result in an underestimation of the risk of depression associated with SCH among the elderly. We also found an insignificant difference in the composite endpoint between the L-T4 supplementation group and placebo group in SCH patients. Data extraction and quality assessment Two authors Zhao and Chen independently extracted the data from the original studies using a uniform standard procedure.

Previously, many studies investigated the relationship between SCH and depression; depression subclinical hypothyroidism and depression, these studies xnd conflicting conclusions. TSH, free T4, and free triiodothyronine T3 were measured at each visit. Therefore, it is likely that a significant number of patients in this study who had subclinical hypothyroidism at baseline had normal TSH levels on repeat measurement. Health status, psychological symptoms, mood, and cognition in L-thyroxine-treated hypothyroid subjects. Forman-Hoffman, V.

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Hypothyroidism requires adequate management and to make it happen, your doctor will probably prescribe thyroid hormone replacement therapy i. Related Articles. AT is responsible for the conception and design depression the original ideas and sublinical manuscript preparation. Overall, we found an insignificant difference in the following composite end point: the SMD for depressive scores was 0. Higgins, J. Methods: We conducted a meta-analysis to evaluate the association between SCH and depression including 1 the prevalence of depression in SCH with a sub-analysis of the geriatric cohort2 thyroid stimulating hormone TSH level among patients with depression and 3 the effect of levothyroxine therapy among patients with SCH and coexistent depression.

Whenever needed, we contacted the authors to obtain either the full-text article or for clarification of the missing data. Thyroid function in different psychiatric disorders. Therefore, hhpothyroidism use of various scales for the detection and quantification of depression may be limited by methodological heterogeneity, disturbing the horizontal comparisons among different studies. CSF somatostatin in affective illness. Save Preferences. In this analysis, explicit criteria were applied in our extensive literature search and investigators were contacted for clarification whenever necessary. Risk of depression among geriatric patients with subclinical hypothyroidism.

  • Among these 21 studies, 8 showed significant associations between SCH and depression, while the other 13 did not show this relationship.

  • You can also search for this author in PubMed Google Scholar.

  • First, timely screening and intervention of depressive symptoms are of great importance in persons with SCH. Encourages teens to seek emotional support from other adults, school counselors, and youth support groups such as Alateen, and provides a resource list.

  • Abstract The objective of this study was to evaluate the relationship between subclinical hypothyroidism SCH and depression. In a sensitivity analysis including only 3 studies that were not only conducted in elderly participants, we found an overall SMD of 0.

High serum TSH levels hypothyroiidism associated with depression in the elderly. This is also the time when women are either approaching or they have gone through a menopause transition. Depression or Hypothyroidism. In recent years, many publications have paid increasing attention to the relationship between SCH and depression; however, these studies revealed tremendous heterogeneity in the recruited population, particularly in terms of age, gender, and depressive domains.

Haggerty JJ, Jr. Permissions Icon Permissions. We also reviewed references ahd the and depression article, reviews and clinical guidelines to identify additional eligible trials. Article Google Scholar This method can lead to the potential misclassification of normal thyroid hormone participants who only have a transient elevation in the serum TSH level.

Introduction

Limit characters or approximately words. Villar H. If you wish to read unlimited content, please log in or register below. The clinical significance of subclinical thyroid dysfunction. Figure 2.

Objective To assess the effect of levothyroxine on the development of depressive symptoms in older adults with subclinical hypothyroidism in the largest trial on depression subclinical hypothyroidism and depression subject and to update a previous meta-analysis including the results from this study. First, major affective symptoms are not associated with subclinical hypothyroidism but are likely due to independent psychiatric diagnoses, which are common in the general population and occur with similar frequency in patients with subclinical hypothyroidism. Levothyroxine overuse: time for an about face? Please review our privacy policy.

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Selected studies were eligible if they met the following criteria: 1 SCH was confirmed by elevated TSH levels and circulating thyroid hormones within the normal range; and 2 the study was a cross-sectional, case-control, or cohort study. You should consult with your doctor or another qualified health care professional before you start taking any dietary supplements or engage in mental health programs. In one large cross-sectional study, there was no association between the Thr92Ala polymorphism in deiodinase 2 and quality of life in euthyroid patients 18but in another study, L-T4—treated patients with the same polymorphism had decrements in psychological well-being and mood compared with patients without this polymorphism Minerva Endocrinol. Bono, G. Keywords: subclinical hypothyroidism, depression, thyroid, neuroendocrinology, thyroxine.

We excluded studies that included individuals who had been treated for thyroid disorders. If you have health insurance, you are encouraged to contact your insurer for a list of participating health care providers and facilities. Clin Endocrinol Oxf. No, we do not provide counseling. DeSA U.

Acknowledgments

For part I, we examined the prevalence of depression in individuals with SCH compared with healthy controls. Shan, Z. The hazard ratio for incident depressive symptoms in subclinical hypothyroid versus euthyroid participants was 0. Pasqualetti, G.

Sincemany physicians have used thyroid hormones for the treatment of depression [ 22 ]. Results The participants were hypothyroid patients Female; Journal of Thyroid Research. Several reports have demonstrated a connection between SCH and current depressive symptoms, current major depression, and a lifetime history of major depression.

  • Advises kids to take care of themselves by communicating about the problem and joining support groups such as Alateen. Furthermore, several non-placebo controlled trials have demonstrated improvements in depressive scores with L-T4 replacement in SCH patients 36 ,

  • Subclinical hypothyroidism SCH is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life QoL in elderly subjects. Table of Contents.

  • T3 augmentation of antidepressant treatment in T4-replaced thyroid patients.

  • Arq Bras Endocrinol Metabol. In a sensitivity analysis, we excluded studies that were only conducted in elderly participants from the meta-analysis.

However, exclusion of outlier TSH levels would likely only strengthen their conclusions. Article Google Scholar. Center for Epidemiologic Studies—Depression. Overt hypothyroidism is a cause of major mood disorder, including melancholia, and may result in deteriorating dementia 1. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. This meta-analysis demonstrates that SCH is not connected to depression. Third, there may be possible bias due to the heterogeneity of the analyzed studies in terms of the definition of SCH and the evaluation of depression.

Low mood and response to Levothyroxine treatment in Indian patients with subclinical hypothyroidism. To avoid missing any relevant papers, we also reviewed the reference lists of key reports for related articles. The Journal of Clinical Endocrinology and Metabolism recently published a prospective study evaluating the association between subclinical hypothyroidism and incident depression in young and middle-aged adults. Demartini et al. High serum TSH levels are associated with depression in the elderly.

Publications

They are more prevalent in women, especially during menopause time, and they share some symptoms. Leave a reply Cancel reply. PMID: Int J Neurosci. Psychopathological and cognitive features in subclinical hypothyroidism.

View Metrics. The NOS scale was developed to assess the quality of non-randomized case-control studies for interpretation of meta-analysis results. Pooled analysis for subclinical hypothyroidism and depression. J Clin Invest. Among other indicators, depressive symptoms are a common reason for starting levothyroxine therapy in patients with subclinical hypothyroidism. Current guidelines on subclinical hypothyroidism recommend taking into account age, TSH levels, and the presence of related symptoms when deciding whether to treat a patient with subclinical hypothyroidism with levothyroxine. Memory improvement with treatment of hypothyroidism.

J Nerv Mental Dis. Larisch et al. Our website uses cookies to enhance your experience. All extracted data were reviewed by HSL. Many papers have investigated whether SCH promotes depression-like behaviour in rats in conjunction with slight hyper-activity of the hypothalamus-pituitary-adrenal HPA axis.

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Numerous depression subclinical hypothyroidism and depression have investigated the mechanism by which overt thyroid disease influences physical, behavioural, and cognitive functions 9 ; however, the connection between SCH and these consequent measures has not been rigorously defined, and studies have reported contradictory outcomes 12131415 Subjects Depression Human behaviour. Brennan, M. The total number of the cases and controls was sufficiently large to support our conclusions.

The cohort depression subclinical hypothyroidism and depression drawn largely from employees of local companies and government agencies and their spouses and so was younger and likely healthier than the overall population. Characteristics of Included Studies The characteristics of 21 studies were presented in Table 1which included 11 cohort, 5 cross-sectional, and 5 case-control studies with mean participant age of Last, all medication information was obtained through patient and relative interviews rather than from medical records. Ge, J. Arq Bras Endocrinol Metabol.

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No significant difference was observed in the composite end point between the L-T4 therapy group and placebo group in SCH patients Fig. Talk to your doctor if you think deprression an underlying thyroid condition might be contributing to symptoms of depression, anxiety, or another mental health condition. This is based on the rationale that many L-T4—treated hypothyroid patients have low serum levels of the active thyroid hormone T3 despite normal TSH levels and high-normal to mildly elevated free T4 levels 3. Supplementary Figure 3 1. Download references.

Although studies with the aim to identify the optimal TSH cut-off point are often population-based, comparison of the findings suggests that a TSH cut-off point with respect to depression is in accordance to them. Whybrow, P. For instance, Kim J. We also observed no relationship between SCH and depression in older patients. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Publication types

Six studies involved community-dwelling healthy individuals [ 1217202123dspression ] while the remaining nine single-centre studies recruited out-patients who were depression subclinical hypothyroidism and depression for suspected SCH [ 71314151619222430 ]. Prog Neuro-Psychopharmacol Biol Psychiatry. Encourages teens to seek emotional support from other adults, school counselors, and youth support groups such as Alateen, and provides a resource list. The total number of the cases and controls was sufficiently large to support our conclusions.

Subclinical hypothyroidism depressipn depression: a meta-analysis. Parsaik AK, et al. Treatment of depression usually revolves around the use of antidepressants together with therapy sessions. Third, possible bias may have existed due to the heterogeneity of the meta-analysed studies in terms of SCH definition based on the upper limit of TSH and in the depressive evaluations diagnosis of depression and depressive scales. Hypothyroidism: More common in women.

Concerning T3 the evidence is more conclusive and it shows the levels of this hormone tend to reduce in the presence of depression. However, a recent study 24 reported the opposite conclusion. SE, standard error; OR, odds ratio. If published papers only provided the percentage of depressive symptoms, the evaluator calculated the numbers of participants by the calculator in Revman version 5. The odds ratio OR for depressive patients was 1. Thyroid medications are sometimes combined with antidepressants to treat depression in people with normal thyroid functioning.

Did you know that symptoms of depression and hypothyroidism are similar too? Many studies have been conducted on this subject, but they yielded different results. Brain glucose metabolism in hypothyroidism: a positron emission tomography study before and after thyroid hormone replacement therapy. Dissent was resolved by consensus and the recommendation of a third observer Zhao as required. The sensitivity bias analysis of these original articles revealed no variation in the orientation of the OR when each publication was omitted Supplementary Figure 3. Data extraction and quality assessment Two authors Zhao and Chen independently extracted the data from the original studies using a uniform standard procedure.

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This finding is similar to our results. Two reviewers screened potential articles independently and a third reviewer made the final decision when discrepancies were found with a specific study. For this reason, it is routine clinical practice to screen patients with depression for thyroid dysfunction. The quality of the included papers was moderate or good, and the NOS scores ranged from five to seven Table 1.

Consent for publication Not applicable. Reference interval for thyrotropin in a ultrasonography screened Korean population. Thyroid imbalances can also contribute to mood problems such as depression and anxiety. Article Google Scholar This meta-analysis demonstrates that SCH is not connected to depression. The quality of the literature for the analyzed studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale.

In cases of overt thyroid disorder, treating psychiatric symptoms with Deptession supplementation is well indicated. The role of thyroid hormones in depression. As seen above, statistics show that depression is more common in women than men and studies support that. Therefore, it is likely that a significant number of patients in this study who had subclinical hypothyroidism at baseline had normal TSH levels on repeat measurement. Surks, M.

Introduction

Many papers have investigated whether SCH promotes depression-like behaviour in rats in conjunction with slight hyper-activity of the hypothalamus-pituitary-adrenal HPA axis. The quality of the included papers was moderate or good, and the NOS scores ranged from five to seven Table 1. Search Search articles by subject, keyword or author.

First, GDS scores were low in our study population at baseline as reflected in the general population. J Clin Endocrinol Metab. J Affect Disord. Effects of subclinical hypothyroidism treatment on psychiatric symptoms, muscular complaints, and quality of life. Study results revealed that incident depressive symptoms occurred in 7, participants.

  • Finally, seven studies were eligible and included in the final quantitative analysis meta-analysis.

  • We selected papers officially published in English.

  • The thyroid axis and depression.

  • Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults.

  • The connection between underactive thyroid and depression is strong enough that the American Association of Clinical Endocrinologists suggests that all people diagnosed with depression should be evaluated for subclinical or clinical hypothyroidism.

Asian And depression. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. In addition, all participants were not limited by age group, geographical region, or race. Exercise performance in young and middle-aged female patients with subclinical hyperthyroidism. Subclinical hypothyroidism: psychiatric disorders and symptoms. Subclinical hypothyroidism and incident depression in young and middle age adults.

No, we do not provide counseling. Zhao View author publications. Gulseren et al. View author publications. Key Points Question Does levothyroxine treatment have an effect on the development of depressive symptoms in older adults with subclinical hypothyroidism? J Nerv Ment Dis.

Clin Med Insights Endocrinol Diabetes. Given the findings summarized above and the valuable contribution by Kim et al. The characteristics of 21 studies were presented in Table 1which included 11 cohort, 5 cross-sectional, and 5 case-control studies with mean participant age of Manciet et al.

Our findings can potentially influence the clinical practice and improve the quality of life of patients. Results Figure 1 shows the flow of studies selection. The sample sizes ranged from 22 to Who is afraid of non-normal data?

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Am J Psychiatry. Hong et al. The clinical significance of subclinical thyroid dysfunction. Download citation. The thyroid axis and depression. You are using a browser version with limited support for CSS.

Thyroid hormones depression subclinical hypothyroidism and depression the treatment of depression: an examination of basic hormonal actions in the mature mammalian brain. Please login or register first to view this content. However, in animal studies, thyroid hormones affect hypotgyroidism neurotransmission of serotonin and noradrenaline, which play critical roles in the pathogenesis of depression and are the targets of current antidepressant therapy 383940 Their mean age did not differ from the euthyroid controls If the Cochrane Q test result was significant, we pooled the data using the DerSimonian—Laird random-effects modelling; otherwise, Hedges-Olkin fixed-effects modelling was used. Zhao Authors T. Eight studies reported the mean depression scores between individuals with SCH and healthy controls, of which five used HDRS [ 1213151622 ] and three used BDI [ 172324 ].

Background

Trial Protocol. Based on these outcomes, it seems difficult to believe that L-T4 treatment truly improves depressive symptoms in SCH patients; this conclusion is supported by the similar outcomes in the L-T4 treatment and placebo groups. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

In fact, various studies have introduced different population-based cut-off points in individuals depression subclinical hypothyroidism and depression any clinical or serological evidences of thyroid disease. Depression and anxiety in different thyroid function states. SCH, subclinical hypothyroidism; CI, confidence interval. Clinical utility of the item geriatric depression scale GDS for use with young and middle-aged adults. Article Navigation. Mental changes accompanying thyroid gland dysfunction. Corroborating this clinical impression, a recent report from the United Kingdom showed that L-T4 is being prescribed more frequently and for more mild degrees of hypothyroidism 2.

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  • Various factors could be behind this unusual state.

  • The sensitivity bias analysis of these original articles revealed no variation in the orientation of the OR when each publication was omitted Supplementary Figure 3. Discussion Present updated meta-analysis of 21 studies reported nearly 2.

  • Register for free and gain unlimited access to:. Second, participants lost to follow-up had a higher mean GDS score at baseline compared to those with a completed follow-up, which suggests that participants with higher scores were more likely lost to follow-up.

  • Depressive symptoms in patients with subclinical hypothyroidism--the effect of treatment with levothyroxine: a double-blind randomized clinical trial. Supplementary Figure 6.

You can also search for this author in PubMed Google Scholar. Journal of Thyroid Research Sep. TSH, free T4, and free triiodothyronine T3 were measured at each visit. Subclinical hypothyroidism SCH is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life QoL in elderly subjects.

Please login or register first to view this content. This method can lead to the potential misclassification of normal thyroid hormone participants who only have a transient elevation in the serum TSH level. Support Center Support Center. Citing articles via Web of Science 4. Subclinical hypothyroidism: summary of evidence in

Pasqualetti, G. Stott, D. With this clinical context, what do we know objectively about depression and mild or subclinical hypothyroidism? All data analyses were performed with Revman 5.

General Psychiatry. An approach for development of age- gender- and ethnicity-specific thyrotropin reference limits. Rates of depression could be even higher than estimates show. First, the age of subjects in the included studies was not restricted to a specific range. However, sub-group analysis according to age found that SCH is related to depression in younger patients, but not in older patients.

However, these qualitative observations are limited by different sample sizes. Prog Neuro-Psychopharmacol Biol Psychiatry. Statistical analysis All data analyses were performed using Stats Direct version 2. Subsequently, we collected the full versions of the qualified reports.

Download PDF. Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults. Advance article alerts.

Cite this article Loh, H. Thyroid 26— Participants were followed up for a minimum of 12 months. It Feels So Bad: It Doesn't Have To Provides information about alcohol and drug addiction to children whose parents or friends' parents might have substance abuse problems. The baseline characteristics of the 45 excluded participants were similar to those who were included eTable 1 in Supplement 2. United Nations.

Levothyroxine overuse: time for an about face? Another interesting phenomenon was observed in terms of age stratification. Davis JD, Tremont G. Inthe Helpline receivedcalls. Studies Sections and Data Extraction Selected studies were eligible if they met the following criteria: 1 SCH was confirmed by elevated TSH levels and circulating thyroid hormones within the normal range; and 2 the study was a cross-sectional, case-control, or cohort study. No, we do not provide counseling.

They further recommend treatment of both SCH and depression to prevent suicide and major depression. Get free access to newly published articles. United Nations. We conducted a meta-analysis to evaluate the association subxlinical SCH and depression including 1 the prevalence of depression in SCH with a sub-analysis of the geriatric cohort2 thyroid stimulating hormone TSH level among patients with depression and 3 the effect of levothyroxine therapy among patients with SCH and coexistent depression. Subclinical hypothyroidism SCH is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life QoL in elderly subjects.

All other studies used different but validated scales to diagnose depression. Thus, in elderly populations, depression is more likely to occur in participants with SCH. Leading chemical drugs dispenses in England in Skip to main content Thank you for visiting nature. Article Google Scholar 2. Inan animal study illustrated that the density of hippocampal T3 was slightly lower in the SCH group than the sham group, which indicated a dysfunction in thyroid hormones in the brains of SCH rats even though their plasma thyroid hormones were in the normal range

We conducted a meta-analysis to evaluate the association between SCH and depression including 1 the prevalence of depression in SCH hypothyeoidism a sub-analysis of the geriatric cohort2 thyroid stimulating hormone TSH level among patients with depression and 3 the effect depression subclinical hypothyroidism and depression levothyroxine therapy among patients with SCH and coexistent depression. The case-control study by Yu et al. Register for free and gain unlimited access to:. Five studies showed higher depression scores among patients with SCH than control group [ 1216222324 ]. Studies Sections and Data Extraction Selected studies were eligible if they met the following criteria: 1 SCH was confirmed by elevated TSH levels and circulating thyroid hormones within the normal range; and 2 the study was a cross-sectional, case-control, or cohort study. Mental changes accompanying thyroid gland dysfunction.

Eur J Endocrinol. We also observed no relationship between SCH and depression in older patients. Get our free guide when you sign up for our newsletter. Talaei, A. J Clin Endocrinol Metab.

High serum TSH levels are associated with depression in suhclinical elderly. Gussekloo et al. Villar H. In a sensitivity analysis including only 3 studies that were not only conducted in elderly participants, we found an overall SMD of 0. Leading chemical drugs dispenses in England in Current guidelines on subclinical hypothyroidism recommend taking into account age, TSH levels, and the presence of related symptoms when deciding whether to treat a patient with subclinical hypothyroidism with levothyroxine.

In several studies, no association could be found between depression and TSH levels, and there was no hypotyhroidism to reduce the upper and depression limit for TSH level [ 35 ]. Forman-Hoffman, V. In addition, levothyroxine replacement therapy could lead to the symptomatic improvement of depression [ 9 ]. Many patients in spite of being euthyroid present with symptoms such as sleep disorders, fatigue, and depression in particular [ 15 ]. Also, the chance to have TSH level below 4 in severely depressed people in comparison to subjects without depression is just 0. AC contributed to the designing and manuscript preparation.

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