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Eml4 protein function in the body – Echinoderm microtubule-associated protein-like 4

Reliability Supported Approved.

Lucas Cox
Tuesday, November 6, 2018
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  • The sequence BAA differs from that shown.

  • Chr Cell type Any Alveolar cells type 1 Alveolar cells type 2 B-cells Basal glandular cells Basal keratinocytes Bipolar cells Cardiomyocytes Cholangiocytes Ciliated cells Club cells Collecting duct cells Cone photoreceptor cells Cytotrophoblasts Distal tubular cells Ductal cells Early spermatids Endothelial cells Enterocytes Erythroid cells Exocrine glandular cells Extravillous trophoblasts Fibroblasts Glandular cells Granulocytes Hepatocytes Hofbauer cells Horizontal cells Intestinal endocrine cells Ito cells Kupffer cells Late spermatids Leydig cells Macrophages Melanocytes Monocytes Mucus-secreting cells Muller glia cells Pancreatic endocrine cells Paneth cells Peritubular cells Proximal tubular cells Rod photoreceptor cells Sertoli cells Smooth muscle cells Spermatocytes Spermatogonia Suprabasal keratinocytes Syncytiotrophoblasts T-cells Undifferentiated cells Urothelial cells.

  • For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression. Truncated N-terminus.

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Fry ; Andrew M. You could not be signed in. Pathway Commons web resource for biological pathway data More All Issues. Cervix, uterine.

Cell type Any Alveolar cells type 1 Alveolar cells type 2 B-cells Basal glandular cells Basal keratinocytes Bipolar cells Cardiomyocytes Cholangiocytes Ciliated cells Club cells Collecting duct cells Cone photoreceptor cells Cytotrophoblasts Distal tubular cells Ductal cells Early spermatids Endothelial cells Enterocytes Erythroid cells Exocrine glandular cells Extravillous trophoblasts Funcrion Glandular cells Granulocytes Hepatocytes Hofbauer cells Horizontal cells Intestinal endocrine cells Ito cunction Kupffer cells Late spermatids Leydig cells Macrophages Melanocytes Monocytes Mucus-secreting cells Muller glia cells Pancreatic endocrine cells Paneth cells Peritubular cells Proximal tubular cells Rod photoreceptor cells Sertoli cells Smooth muscle cells Spermatocytes Spermatogonia Suprabasal keratinocytes Syncytiotrophoblasts T-cells Undifferentiated cells Urothelial cells. Category Cell line enriched Group enriched Cell line enhanced Low cell line specificity Not detected Detected in all Detected in many Detected in some Detected in single Is highest expressed. Bronchus Respiratory epithelial cells:. Echinoderm microtubule-associated protein-like 4. General description of the gene and the encoded protein s using information from HGNC and Ensemblas well as predictions made by the Human Protein Atlas project. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. Alternative splicing of this gene results in two transcript variants.

Detection or not of the gene in blood, based on spectral body estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas. Type Protein Rna. The image is clickable and will redirect to more Blood Atlas data. Expression Not detected Low Medium High. Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The additional location s may not be present i all cell lines and may have lower staining intensity compared to the main location s.

What are proteins made of?

Liver Cholangiocytes:. A yellow triangle on the bar indicates a Below the antigens, the maximum funftion sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues HsID 10 or 50 aa residues HsID Cell type. View primary data.

Continuous Update Project Expert Report Alternative name s :. A novel case of an aggressive superficial spindle cell sarcoma in an adult resembling fibrosarcomatous dermatofibrosarcoma protuberans and harboring an EML4-NTRK3 fusion. Images, videos and audio are available under their respective licenses. Database for complete collections of gene phylogenies More Am J Dermatopathol. The curve in blue displays the predicted antigenicity i.

Microtubule-binding 2 Publications Manual assertion based on experiment in i Ref. Cell Res. In addition, a variable number of bi- tri- or multinucleated, spindled, multilobated, cells with eccentric nuclei, cells with nuclear pseudoinclusions, mucinous, and grooved cells were admixed. Spleen Cells in red pulp:. Low tissue specificity. This gene is a member of the echinoderm microtubule associated protein-like family.

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Alternative splicing of this gene results in two transcript bdy. Protein can serve as a valuable energy source but only in situations of fasting, exhaustive exercise or inadequate calorie intake. Parathyroid gland Glandular cells:. This allows the antibodies to respond quickly the next time a particular disease agent invades your body Corresponds to variant dbSNP:rs Ensembl.

Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Share on Pinterest. ExpressionAtlas i. Show all Align All.

  • Homo sapiens Human. Select a section on the left to see content.

  • Parent protein classes are in bold font and subclasses are listed under the parent class. Pap, 92, pp.

  • TreeFam i. Human Protein Atlas More

  • B-cells and granulocytes.

Adrenal gland. Protein interaction database and analysis system More EPD i. Cell cycleCell divisionMitosis. Your body also uses amino acids from broken-down skeletal muscle if carbohydrate storage is low. Our requirement for protein depends on our stage of life and most Europeans consume enough to meet their requirements. PhosphoSitePlus i.

This protein is involved in cancers when spliced with the anaplastic lymphoma kinase. The gray human body provides links to a histology dictionary when clicking on any part of the figure. Category Cell type enriched Group enriched Cell type enhanced Low cell type specificity Not detected Detected in all Detected in many Detected in some Detected in single Is highest expressed. F-circEA-2a mainly locates in the cytoplasm and promotes cell migration and invasion, but has little effect on cell proliferation. Anticancer Res. Mol Cancer Res. This is a detailed review of the weight loss effects of protein.

Automatic assertion according to sequence analysis i. A review of ALK-rearranged renal cell carcinomas with a focus on clinical and pathobiological aspects. Duodenum Glandular cells:. Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.

Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary th accession number'. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Don't show this again.

Length: Current concepts and unresolved questions in dietary protein requirements and supplements in adults. Transport proteins carry substances throughout your bloodstream — into cells, fjnction of cells or within cells. This is known as the 'taxonomic identifier' or 'taxid'. In addition, targeted next generation sequencing allowed us to analyze a set of 23 driver genes in a single assay. Low immune cell specificity. These body proteins are continually being repaired and replaced throughout our lives.

Low human brain regional specificity. Genes Eml4 protein function in the body Cancer. Several mechanisms of resistance to these inhibitors have been described and new strategies are underway to overcome the limitations of current ALK inhibitors. BMC Cancer. For 9 fusions spiked-into RNA-seq libraries with different concentrations, the pipeline was able to detect all in unfiltered results although some at very low concentrations may be missed when filtering was applied. Don't show this again. Echinoderm microtubule-associated protein-like 1 is a protein that in humans is encoded by the EML1 gene.

GeneRIFs: Gene References Into Functions

Protein interaction database and analysis system More The view of microbes as energy converters illustrates the trade-off between growth rate and yield. Parathyroid gland Glandular cells:. Revision Received:. BioGRID i.

PDBj i Links Updated. Sign in Don't already have an account? Tissue proteome. Pancreas Exocrine glandular cells:.

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We report the first real-world cohort of comprehensive genomic assessments of patients with non-small-cell function the cancer NSCLC in a Chinese population. Images of selected tissues give a visual summary of the protein expression profile furthest to the right. Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance. The image is clickable and will redirect to more Cell Type Atlas data. The five-year survival rate was

  • Additional locations are characterized by either a markedly lower staining intensity than the main location, or that it is only observed in a subset of the cell lines.

  • National Library of Medicine. Some proteins are hormoneswhich are chemical messengers that aid communication between your cells, tissues and organs.

  • B-cells and granulocytes.

  • This article compares animal and plant proteins.

GenAtlas i. Manual assertion based on experiment in i. These proteins include keratin, collagen and elastin, which help form the connective framework of certain structures in your body The image is clickable and will redirect to more Blood Atlas data.

This means, if a small number of plant foods are consumed as the only protein sources, they are unlikely to supply enough essential amino acids to meet our requirements. Endocrine tissues. Colon Endothelial cells:. View primary data.

Related Research Articles

ProteomicsDB: a multi-organism proteome resource More The Blood Atlas contains single cell type RNA information covering various immune cells in the blood, e. Corresponds to variant dbSNP:rs Ensembl.

This review summarizes current literature data on the heterogeneity of PD-L1 expression and the relationship with such factors and with clinicopathological features of NSCLC. This article compares animal and plant proteins. FAO Food Funvtion. Figure 4. Figure 2 shows the protein content found in a typical serving of common animal and plant-based foods. Your basket is currently empty. Meanwhile, in one of 36 RET fusion-negative cell lines, RET mRNA levels at the C-terminus were elevated at least fold compared with the median of all 37 cell lines, and high C-terminal protein expression was detected despite the absence of RET fusion.

  • Human Gene Nomenclature Database More

  • Read this next. Genevisible i.

  • The Gene Wiki collection of pages on human genes and proteins More You do not currently have access to this content.

  • The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.

GeneCards: human genes, protein and diseases More GenAtlas i. Class Biological process Molecular function Disease. Caudate Glial cells:.

HGNC i. In addition localized to the Intermediate im, Cytosol. Summary of data presented in the Cell Type Atlas and an interactive image showing mRNA expression in cell type groups e. Organ Expression Alphabetical. Gene product is not prognostic. Nevertheless, interest in these proteins has grown substantially because of the identification of EML mutations in neuronal disorders and oncogenic fusions in human cancers.

What do proteins do for the body?

The additional location s may not be present i all cell lines and may have lower staining proteib compared to the main location s. This is a form of severe protein malnutrition called kwashiorkor that develops when a person is consuming enough calories but does not consume enough protein Comparison with other variant specific tools showed good performance of the pipeline. Echinoderm microtubule associated protein like 4. GenAtlas: human gene database More

Category Cell line enriched Group enriched Cell line enhanced Low cell line specificity Not detected Detected in all Detected in many Detected in some Detected in single Is highest expressed. Small intestine Glandular cells:. ENSG version Integrated resource of protein families, domains and functional sites More KEGG i. Reliability Enhanced Supported Approved Uncertain.

The summary is based on knowledge-based annotation. For example, hemoglobin is a protein that carries oxygen from your lungs to body tissues. International society of sports nutrition position stand: protein and exercise. A novel case of an aggressive superficial spindle cell sarcoma in an adult resembling fibrosarcomatous dermatofibrosarcoma protuberans and harboring an EML4-NTRK3 fusion. ISBN Sustainable healthy diets — Guiding principles.

SignaLink i. Genevisible i. Bone marrow Hematopoietic cells:. Close Modal.

Soft tissue 1 Soft tissue 2 Chondrocytes:. Database for complete collections protei gene phylogenies More GO [protein binding]. Class Biological process Molecular function Disease. This protein, termed EMAP for echinoderm MAP, was the major non-tubulin component present in purified microtubule preparations made from unfertilized sea urchin eggs [J. By continuing to use our website, you are agreeing to our privacy policy. Male tissues.

  • These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. All Issues.

  • The encoded WD-repeat protein may be involved in microtubule formation.

  • Pharos i.

  • Official gene symbol, which is typically a short form of the gene name, according to HGNC.

Human Gene Nomenclature Database More The sequence of this isoform differs from the canonical sequence as follows: : Missing. Assigned HPA protein class es for the encoded protein s. CCDS i. See complete history.

Antibodies Yes No. Adrenal gland. All organs. Reactome - a knowledgebase of biological pathways and processes More Enzymes are proteins that aid the thousands of biochemical reactions that take place within and outside of your cells 7.

GeneWiki i. Muscle tissues. Manual assertion inferred from combination of experimental and computational evidence i. Select a section on the left to see content.

Category Lineage enriched Group enriched Lineage enhanced Low lineage specificity Not detected Detected in all Detected in many Detected in single Is highest expressed. Human Protein Atlas More Fats supply the most energy, at nine calories per gram. Cancer Overview. Adrenal gland. References EFSA Enzymes are proteins that aid the thousands of biochemical reactions that take place within and outside of your cells 7.

PRO i. Sign in Don't already have an account? The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Parent protein classes are in bold font and subclasses are listed under the parent class.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Gallbladder Glandular cells:. GeneCards: human genes, protein and diseases More Appendix Glandular cells:. EML proteins in microtubule regulation and human disease Andrew M.

The categories include: cell type enriched, group enriched, cell type proten, low cell type specificity and not detected. Genevisible i. The Blood Atlas contains single cell type RNA information covering various immune cells in the blood, e. Integrated resource of protein families, domains and functional sites More Q9HC35 [Direct mapping] Echinoderm microtubule-associated protein-like 4. Encyclopedia of Proteome Dynamics More

Testis Elongated or late spermatids:. RNA tissue specificity: Low tissue specificity. May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. Sign in via your Institution Sign in via your Institution. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Expression Detection All organs. Spinal cord.

Homo sapiens Human. Reactome i. As the name suggests, essential amino acids cannot be produced by the body and therefore must come from our diet.

  • Show all Align All.

  • What are proteins made of? The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

  • Advanced Search.

  • InParanoid i. Our requirement for protein depends on our stage of life and most Europeans consume enough to meet their requirements.

Antibodies used for this assay. Antibodies Yes No. Images of selected tissues give a visual summary of the protein expression profile furthest to the right. Cerebral cortex. Medium consistency between antibody staining and RNA expression data. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected.

The study group consisted of 8 female and 6 male patients, ranging in age from 18 to 79 years mean 42 years; median The structure of enzymes allows them to combine with other molecules inside the cell called substrates, which catalyze reactions that are essential to your metabolism 8. This is a detailed review of the weight loss effects of protein. Spinal cord. Animal and plant-based proteins also differ in their bioavailability and digestibility. Sustainable healthy diets — Guiding principles. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.

SMR i. Protein Ontology More This allows the antibodies to respond quickly the next time a particular disease agent invades your body

Restrictedly overexpressed proliferation-associated protein. Specificity of RNA expression in 17 cancer types is categorized as potein cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Epididymis Glandular cells:. Category Cell line enriched Group enriched Cell line enhanced Low cell line specificity Not detected Detected in all Detected in many Detected in some Detected in single Is highest expressed. Low tissue specificity.

Human Protein Atlas More The additional location s may not be present i all cell lines and may have lower staining intensity compared to the main location s. GeneWiki i. DMDM i. Short name:.

Number of papers are based on searches of PubMed click on topic title for arbitrary criteria used. Kwashiorkor is rare in developed regions of the world and occurs more often in areas of starvation. Medical condition. Once your body has produced antibodies against a particular bacteria or virus, your cells never forget how to make them. Thyroid gland Glandular cells:. Alectinib may show unsatisfactory therapeutic effects for this kind of ALK fusion.

In addition, targeted next generation sequencing allowed us to analyze a set of 23 driver genes in a single assay. For people who consume little to no animal-based foods, such as vegans or vegetarians, it is important that they consume protein from sources with complementary limiting amino acids. The sequence of this isoform differs from the canonical sequence as follows: : Missing.

View primary data. Cerebral cortex Endothelial cells:. Class Biological process Molecular function Disease. Cell type Proteinn Alveolar cells type 1 Alveolar cells type 2 B-cells Basal glandular cells Basal keratinocytes Bipolar cells Cardiomyocytes Cholangiocytes Ciliated cells Club cells Collecting duct cells Cone photoreceptor cells Cytotrophoblasts Distal tubular cells Ductal cells Early spermatids Endothelial cells Enterocytes Erythroid cells Exocrine glandular cells Extravillous trophoblasts Fibroblasts Glandular cells Granulocytes Hepatocytes Hofbauer cells Horizontal cells Intestinal endocrine cells Ito cells Kupffer cells Late spermatids Leydig cells Macrophages Melanocytes Monocytes Mucus-secreting cells Muller glia cells Pancreatic endocrine cells Paneth cells Peritubular cells Proximal tubular cells Rod photoreceptor cells Sertoli cells Smooth muscle cells Spermatocytes Spermatogonia Suprabasal keratinocytes Syncytiotrophoblasts T-cells Undifferentiated cells Urothelial cells. Expression Detection All organs. Lymph node.

Data table showing topics fhnction to specific cancers and associated disorders. Show all Align All. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Frontiers in nutrition, 4, p.

Article history Received:. Cell type. Gastrointestinal tract.

Gene ib is not prognostic. Select a section on the left to see content. Here are the 11 most nutrient dense foods on earth. Ensartinib is a second generation targeted therapy trial drug Xmanufactured by XCovery. More information. As protein is essential for cell and tissue growth, adequate intake of protein is particularly important during periods of rapid growth or increased demand, such as childhood, adolescencepregnancyand breastfeeding. A high protein diet can boost metabolism and reduce appetite, helping you lose weight.

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Orphanet; a database dedicated to information on rare diseases ij orphan drugs More Length: External id. ChiTaRS i. Common purple and unique grey regions between different splice variants of the gene are also displayed read moreand at the bottom of the protein view is the protein scale. In addition localized to the Intermediate filaments, Cytosol.

Basket 0. Read this next. Spinal cord. Plant Protein — What's the Difference? Thyroid gland. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.

Protein expression data is shown for each of the 44 tissues. Manual assertion inferred from combination of experimental and computational evidence i. Validation Supported Approved Uncertain. Total PBMC. Number of protein-coding transcripts from the gene as defined by Ensembl.

Search Fields » Search result. Read more. Echinoderm microtubule-associated protein-like 4. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar.

Proteins are made up lrotein many building blocks, known as amino acids. Category Cell type enriched Group enriched Cell type enhanced Low cell type specificity Not detected Detected in all Detected in many Detected in some Detected in single Is highest expressed. Ninety patients diagnosed with lung adenocarcinoma underwent surgical pathological classification. Future Oncol.

For example, hemoglobin is a protein that carries oxygen from your lungs to body tissues. Expression Not detected Low Medium High. Reactome - a knowledgebase of biological pathways and processes More Lymph node. ISBN

Each bar represents the highest expression score found in a particular group of tissues. Open Targets More Subsequent selection of a particular tissue in this list links to the image data page. The categories include: detected and not detected, where detection refers to a concentration found in the literature search.

Full view. Search Fields » Search result. Summary of data presented in the Cell Atlas and a representative image of subcellular localization. Liver Cholangiocytes:. Human Gene Nomenclature Database More Mouse-over function shows protein score for analyzed cell types in a selected tissue.

Ductus deferens. The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been eml4 protein function in the body as intracellular will have intracellular as the final location. All transcripts of all genes have been analyzed regarding the location s of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Article history Received:. Vagina Squamous epithelial cells:. The image is clickable and will redirect to more Brain Atlas data. Rectum Glandular cells:.

Small intestine Glandular cells:. ProteomicsDB: a funcrion proteome resource More Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location datahave been further annotated and classified with the aim to determine if the corresponding protein s are secreted or actually retained in intracellular locations or membrane-attached.

This means, if a small number of plant foods are consumed as the only functoin sources, they are unlikely to supply enough essential amino acids to meet our requirements. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. This is known as the 'taxonomic identifier' or 'taxid'. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location s. Grossly, the tumour forms were ill-demarcated or well demarcated solid mass in the renal medulla. Main subcellular location s and reliability score s for the encoded protein s in human cells. As the name suggests, essential amino acids cannot be produced by the body and therefore must come from our diet.

Oral mucosa Squamous epithelial cells:. Phosphorylated during mitosis PubMed: Close Modal. Phosphoserine; by NEK6 Combined sources Manual assertion inferred from combination of experimental and computational evidence i Ref. Cervix, uterine Glandular cells:. Cited By Web Of Science

Orphanet; a database dedicated to information on rare diseases and orphan drugs More TreeFam i. Targeted DNA exome sequencing and DNA methylation profiling were performed on tumor specimens obtained from different patients. Chromosome 17 mouse [2].

Select a section on the left to see content. ExpressionAtlas i. Searches Enhanced Supported Approved Uncertain Intensity variation Spatial variation Cell cycle intensity correlation Cell cycle spatial correlation Cell cycle biologically Custom data cell cycle dependant Cell cycle dependent protein Cell cycle independent protein Cell cycle dependent transcript Cell cycle independent transcript Multilocalizing Localizing 1 Localizing 2 Localizing 3 Localizing 4 Localizing 5 Localizing 6 Main location Additional location. See complete history. Gene name i Official gene symbol, which is typically a short form of the gene name, according to HGNC. Category Cell type enriched Group enriched Cell type enhanced Low cell type specificity Not detected Detected in all Detected in many Detected in some Detected in single Is highest expressed. The Tissue Atlas contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level.

DisGeNET i. Pfam i. PeptideAtlas i. Potential poly-A sequence. Seminal vesicle. The summary is based on knowledge-based annotation. Expression Not detected Low Medium High.

Prognosis Favorable Unfavorable. GenomeRNAi i. Jessica Montgomery ; Jessica Montgomery.

SMART i. ProteomicsDB i. This gene is a member of the echinoderm microtubule associated protein-like family. Pfam i. Small intestine.

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A protein intake of 1. Three datasets were used to evaluate the performance of the pipeline for SNVs, indels and fusion transcripts. S2CID Regarding the procedures, surgery was the most efficient, obtaining only The food choices we make not only affect our health they also affect the environment. Corresponds to variant dbSNP:rs Ensembl.

Cell type. Annotation Intracellular eml4 protein function in the body membrane Secreted - unknown location Secreted in brain Secreted in female reproductive system Secreted in male reproductive system Secreted in other tissues Secreted to blood Secreted to digestive system Secreted to extracellular matrix. Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. Protein is essential for life; it supplies the essential amino acids needed for the growth and maintenance of our cells and tissues.

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