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Iodine induced hypothyroidism occurrence and epidemiology of cancer – Geographic influences in the global rise of thyroid cancer

Le Guen.

Lucas Cox
Tuesday, August 28, 2018
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  • On this basis, overstimulation by thyroid-stimulating hormone TSH was considered to play a major role in tumorigenesis.

  • Cell-phone-based measurement of TSH using Mie scatter optimized lateral flow assays. Uncommon Causes of Thyrotoxicosis.

  • J Clin Endocrinol Metab Polybrominated diphenyl ether PBDE concentrations in house dust are related to hormone levels in men.

Publication types

Ohshima M, Ward JM. In northwestern Spain, iodized salt was introduced in ,the thyroid cancer incidence increased in females from 1. Those rates and their changes over time identify high-risk groups and provide indirect evidence for causes of disease. Hematol Med Oncol 1: Harach, H.

There is evidence that iodine is ihduced major mediator of thyroid autoregulation, involving numerous inhibitory actions According to WHO criteria these levels were considered as mild iodine deficiency, more than adequate iodine and epidemiology excess, respectively. Eur J Nucl Med. Lu C Activation of tumor cell proliferation by thyroid hormone in a mouse model of follicular thyroid carcinoma. J Clin Endocrinol Metab. Am J Cancer Res 1: The effect of iodine excess might be better understood by assessing previous papers which examined the safety of the upper limits of iodine, and observational studies in which a population is exposed to chronic excess iodine.

It occurs that high incidence of multinodular toxic goitre in the elderly population in a low iodine intake area whereas high incidence of Grave's disease in young in a high iodine intake area [56]. Occult thyroid cancers Thyroid cancers that are not detectable by contemporary clinical methods. Jpn J Clin Oncol. Mitotic activity of the endocrine cells in rat thyroid glands during postnatal life. The changing incidence of thyroid cancer. J Trace Elem Med Biol.

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Impact of Iodination on Thyroid Pathology in Africa. Seasonal variation in plasma thyroid hormone concentrations in coastal versus inland populations of juvenile American alligators Alligator mississippiensis : Influence of plasma iodide concentrations. Substances Iodine.

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  • Graves Disease Diffuse Hyperplasia.

  • The role of iodine in carcinogenesis.

  • The study from Kuwait, high intake of cabbage showed an increased risk with a borderline significance []. They also concluded that occurrence of hypothyroidism was mainly due to autoimmune thyroiditis [ 17 ].

  • The use of iodised salt in the manufacturing of processed foods in South Africa: bread and bread premixes, margarine, and flavourants of salty snacks.

Iodine Supplementation. OKEN, R. BilekJ. Close Figure Viewer.

Iodine deficiency, therefore, may result in a decrease of thyroid cell growth negative regulation. Medications, radiation or other unnatural sources of iodine except oral supplementation were excluded in this systematic review. Coefficient of determination r 2 and p-value are derived from the linear regression model. Franceschi S. Hoffman, K.

Carneiro-Pla and the other, anonymous, reviewer s for their contribution to the peer review of this work. Increased serum vascular endothelial growth factor levels and intrathyroidal vascular area in patients with Graves disease and Hashimotos thyroiditis. Yamashita, H. Figure 2. Bouvard, V.

INTRODUCTION

Iodination of T4 at residue 5 in the Tg chain. J Stat Softw. Cancer incidence and incidence rates in Japan in a study of 32 population-based cancer registries for the monitoring of cancer incidence in Japan MCIJ project.

  • In DHPN-treated rats, both conditions significantly increased thyroid follicular tumorigenesis. Nat Rev Endocrinol.

  • Thyroid Vol.

  • Thyroid hormone biosynthesis.

  • Nippon Naibunpi Gakkai Zasshi Analysis of 3, fine-needle aspiration biopsy cases in Poland between and showed that the frequency of cytologically-diagnosed chronic thyroiditis increased from 1.

  • Trace iodine quantitation in biological samples by mass spectrometric methods. Alcohol consumption is associated with reduced prevalence of goitre and solitary thyroid nodules.

  • Ann Chimie Phys

Contrast-induced thyrotoxicosis. Classification of Thyroid Diseases: Suggestions iodime a Revision. A critical review of modern and emerging absorbent dressings used to treat exuding wounds. Hyperthyroidism secondary to hysterosalpingography. Urinary iodine excretion in pregnant women residing in areas with adequate iodine intake. Cited By Excessive intake of iodine and low prevalence of goiter in school age children five years after implementation of national salt iodization in Shebedino woreda, southern Ethiopia.

Iodine intake as a determinant of thyroid disorders in populations. Effect of excess iodine intake on thyroid diseases hypothyroieism different populations: A systematic review and meta-analyses including observational studies. These changes may occur in localized foci within the gland or in the process of nodule formation. Urinary iodine excretion in pregnant women residing in areas with adequate iodine intake. Le Guen.

Dietary iodine intake, thyroid diseases and the prevalence of papillary carcinoma (PTC)

Duntas LH. View author publications. Coindet J Nouvelles recherches sur les effects de l'iode,et sur les cautions survere dansle traitment du goiter par ce nuveau remide. Excess iodide therefore exerts a negative control on different thyroid parameters, inhibiting iodide uptake and organification, protein and RNA biosynthesis, hormone secretion, as well as paracrine mitogenic activity on endothelial cells and fibroblasts Figure 4.

Thyroid cancer, thyroiditis and dietary epidemillogy a review based on the Salta, Argentina Model. Also, because presence of a thyroid nodule has a higher likelihood of malignancy in iodine sufficient areas free of endemic goiter, there may be differences inducev diagnostic work-up [ 21 ]. Of note, cancer highest quintile of dietary iodine was greater than three times the WHO RNI for iodine for this age group. A pooled analysis of case—control studies of thyroid cancer: cigarette smoking and consumption of alcohol, coffee, and tea. Risk of thyroid cancer in first-degree relatives of patients with non-medullary thyroid cancer by histology type and age at diagnosis: a joint study from five Nordic countries. Prevalence of thyroid dysfunction with adequate and excessive iodine intake in Hebei Province, People's Republic of China. The native iodine content of milk is low, but the use of iodine-containing supplements for cows and iodophor disinfectants during dairying and transport result in high levels in milk and milk products [ ].

Meanwhile, a standard to assess the iodine nutrition status for pregnant and lactating females based on UIC was proposed and included insufficient, adequate, more than adequate and excessive iodine status categories Table 3. Biochim Biophys Acta. Iodine-induced hyperthyroidism is of concern where iodine supplementation has recently been introduced, but only one adult study, from Zimbabwe, met our inclusion criteria. Program Tech. Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood. Chin J Intern Med chinese

MeSH terms

Urinary iodine concentrations for determining iodine status deficiency in populations. However, many studies only identified the crude percentages of the diseases and did not adjust these variables. Journal of Proteome Research Nodules in cross-sectional studies in adults, children and pregnant women. However, the occurrence of OTC in the two areas was not different: 4.

Comparing Cao county and Shan county, which occcurrence areas with high water iodine, to adequate iodine area such as in Mudan district, an increasing incidence is observed in in Mudan district. The use of iodised salt in the manufacturing of processed foods in South Africa: bread and bread premixes, margarine, and flavourants of salty snacks. Infection and Autoimmune Thyroid Disease. This has been observed in epidemic incidence in several countries when iodine has been given as prophylaxis in a variety of vehicles, but the attack rate as recorded has been low. Jan

Jessica FarebrotherMichael B. TODD Search for more papers by this author. The incidence of autoimmune thyroid disease: a systematic review of the literature. Pemberton's Sign.

A high iodine intake, thyroid diseases and the prevalence of papillary carcinoma (PTC)

Endocrine and Metabolic Agents. Seasonal variation in plasma thyroid hormone concentrations in coastal versus inland populations of juvenile American alligators Alligator mississippiensis : Influence of plasma iodide concentrations. Severe Iodine Deficiency. Are cytologic and histopathologic features of hot thyroid nodules different from cold thyroid nodules?

  • At the International Conference on Goiter, the eminent pathologist Carl Wegelin argued that thyroid cancer was more common in areas of endemic goiter, with frequency at autopsy varying from 1.

  • Iodine nutrition: Disorders, monitoring and policies.

  • WHO Mortality Database.

Influence of iodization programmes on the epidemiology of cabcer goitre. Lower prevalence of mild hyperthyroidism related to a higher iodine intake in the population: prospective study of a mandatory iodization programme. ZamrazilR. Jan Since a rise in thyroid cancer IR was observed. A year Danish population-based study. Urinary iodine and stable isotope analysis to examine habitat influences on thyroid hormones among coastal dwelling American alligators.

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Administration of iodine in almost any chemical form may induce an episode of thyrotoxicosis IIH. Prevalence of hyperthyroidism according to type of vegetarian diet. Cited By Excessive intake of iodine and low prevalence of goiter in school age children five years after implementation of national salt iodization in Shebedino woreda, southern Ethiopia. Thyrotoxicosis: Diagnosis and Management. A Hidden Solution. New User.

Jpn J Med Sci Biol Asia Pac J Public Health. Natl Toxicol. Acta Endocrinol Copenh ; 50 — Geneva, WHO, Nippon Naibunpi Gakkai Zasshi Patterns of cancer in five continents.

Analytical epidemiology consists of case control, often termed retrospective and cohort or prospective studies. Table 1. Currently, the relationship between USI and iodine excess has attracted more attention. J Chin Med Univ chinese

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Sustaining iodine deficiency disorders IDD control programme. This has been observed in epidemic incidence in several countries when iodine has been given as prophylaxis in a variety of vehicles, but the attack rate as recorded has been low. Substances Iodine. TODD, E. Le Guen.

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  • Abstract We have critically reviewed the available information on iodine-induced hyperthyroidism IIH from published sources and other reports as well as the experience of the authors in Tasmania, Zaire, Zimbabwe, and Brazil. Effect on Thyroid Function.

  • Iodine status in healthy pregnant women in Korea: a first report.

We perform a new meta-analysis of pooled measures of effect from case—control studies of total iodine intake and TC. An excess of iodine through dietary intake, drugs or other iodine-containing compounds ot lead to goiter [], hyperthyroidism [], hashimoto's thyroiditis [46] and thyrotoxicosis [] through increasing thyroid hormone synthesis in the presence of underlying thyroid disease, particularly multinodular goiters containing previously existing area of autonomous function. Mutation of thyroid hormone receptor-beta THRbeta in mice promotes the development of mammary hyperplasia via aberrant activation of STAT5 []. High prevalence of autoimmune thyroiditis in schoolchildren after elimination of iodine deficiency in northwestern Greece. Asia Pac J Public Health. However, the occurrence of OTC in the two areas was not different: 4. In a review of Swiss studies beforethe female:male ratio of thyroid cancer in areas of endemic goiter was 1.

Clin Nutr Res 3: Arch Pathol Lubin, J. The UIC urinary iodine concentration in subjects from 29 rural areas were

Are cytologic and histopathologic features of hot thyroid nodules different from anr thyroid nodules? Effects of amiodarone therapy on thyroid function. IIH may also occur with an increase in iodine intake in those whose hyperthyroidism Graves' disease is not expressed because of iodine deficiency. TODD, E. Abstract The controversy that iodine intake may increase the risk of thyroid cancer has heightened over the past twenty years.

Vagenakisand Kostas B. We have critically reviewed the available information on iodine-induced hyperthyroidism IIH from published sources and other reports as well as the experience of the authors in Tasmania, Zaire, Zimbabwe, and Brazil. Can't sign in? Iodine content of salt 2 years after the introduction of the universal salt iodisation legislation in Lesotho. The effects of iodine level and source on iodine carry-over in eggs and body tissues of laying hens.

  • The epidemic of thyroid cancer in the United States: the role of endocrinologists and ultrasounds. Administration of thyroid hormone to thyrectomized rodents is a prerequisite for the induction of hepatomas by chemicals, indicating a role in the initiating action of carcinogen [].

  • In this retrospective study, we mainly analyzed the association between water iodine and thyroid cancer and discussed the possible cause of the increase in thyroid cancer. Sustainability of a well-monitored salt iodization program in Iran: Marked reduction in goiter prevalence and eventual normalization of urinary iodine concentrations without alteration in iodine content of salt.

  • On the other hand, mortality from thyroid cancer tends to be higher in regions of endemic goiter because of more frequent advanced tumor stages at diagnosis and an increased ratio of more aggressive subtypes.

  • Cardiovascular assessment of hyperthyroid patients with multinodular goiter before and after radioiodine treatment preceded by stimulation with recombinant human TSH.

  • Another case study was performed by Solomon et al.

  • Occult carcinomas of the thyroid. High thyroid volume in children with excess dietary iodine intakes.

PubMed Google Scholar 9. References 1. Regarding the study quality of randomized trials, risk of cancer was assessed according to the domains in the Cochrane Handbook for Systematic Reviews of Interventions as follows: 1 iodihe sequence generation, 2 allocation concealment, 3 blinding of participants and personnel, 4 blinding of outcome assessment, 5 incomplete outcome data, and 6 selective reporting [ 17 ]. References 1. Iodine-induced goitre and high prevalence of anaemia among Saharawi refugee women. Geneva: World Health Organization; Incidence rates newly diagnosed cases in a population over a given time period reveal patterns of disease by age, race, sex, ethnic group and geographic localization.

Management of amiodarone-related thyroid problems. Pilot study of urinary iodine concentration and of biochemical thyroid parameters before and after cautious public health intervention on salt iodide content: The Swiss longitudinal — iodine study. Hyperthyroidism secondary to hysterosalpingography. Geoffroyand B. Bismuth iodoform paraffin paste: a review. Changes in iodine excretion in 50—y-old denizens of an Arctic society in transition and iodine excretion as a biomarker of the frequency of consumption of traditional Inuit foods.

Introduction

Medullary thyroid cancer: an update for surgeons. Int J Endocrinol. Toxicol Pathol. Goldberg RC, Chaikoff IL Development of thyroid neoplasm in rat following single injection of radioactive iodine. Clinical recognization of thyroidal hypothyroidism.

Administration of iodine in almost any chemical form may induce an episode of thyrotoxicosis IIH. Global epidemiology of hyperthyroidism and hypothyroidism. We have critically reviewed the available information on iodine-induced hyperthyroidism IIH from published sources and other reports as well as the experience of the authors in Tasmania, Zaire, Zimbabwe, and Brazil. Forgot your username?

The Thyroid. The biological basis for IIH appears most often to be mutational events in thyroid cells that lead to autonomy of function. Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficienty or excess. IIH may also occur with an increase in iodine intake in those whose hyperthyroidism Graves' disease is not expressed because of iodine deficiency.

  • Further studies on induction and growth of thyrotropic pituitary tumors in mice.

  • Iodine Fortification and Hyperthyroidism.

  • MinH. Journal of internal medicine

  • Iodised salt for preventing iodine deficiency disorders. Intravenous Methimazole in the Treatment of Refractory Hyperthyroidism.

Cardiovascular assessment of hyperthyroid patients with multinodular goiter before and after radioiodine treatment preceded by stimulation iodine induced hypothyroidism occurrence and epidemiology of cancer recombinant human TSH. We have critically reviewed the available information on iodine-induced hyperthyroidism IIH from published sources and other reports as well as the experience of the authors in Tasmania, Zaire, Zimbabwe, and Brazil. Iodine nutrition: Disorders, monitoring and policies. We have critically reviewed the available information on iodine-induced hyperthyroidism IIH from published sources and other reports as well as the experience of the authors in Tasmania, Zaire, Zimbabwe, and Brazil.

Also anaplastic thyroid cancer is practically not seen after years of iodine supplementation. In iodine deficient rats, administration of NMU induces thyroid cancer after a shorter latency period and at higher incidence and multiplicity when iodine induced hypothyroidism occurrence and epidemiology of cancer to rats only iodine deficient or to rats that received NMU but were iodine sufficient [ 3132 ]. Suzuki [23] was the first to report a case of endemic seashore goiter following marine algae. Although differences in autopsy methods used for thyroid sectioning and histological examination may bias comparisons, associations between iodine intake in populations and the occurrence of OTC at autopsy may be relatively free of ascertainment bias and therefore valuable.

Occult thyroid carcinomas OTC are often incidentally found at autopsy, and nearly all are papillary microcarcinomas. Regional Committee for Africa. Both group were mostly made up of women Epidemiology of subtypes of hypothyroidism in Denmark.

After restoring the obligatory iodine prophylaxis ina significant decrease in elevated TSH concentration in newborns and urinary iodine concentration increase in schoolchildren were observed. Iodine concentration in commercial cat foods from three regions of the USA, — Goitre prevalence and thyroid abnormalities at ultrasonography: a comparative epidemiological study in two regions with slightly different iodine status. Anatomy and Physiology of the Thyroid Gland.

Thus, thyrocyte exposure to iodine in these cell studies canfer several orders of magnitude above that encountered under physiological conditions resulting from varying dietary iodine intakes. Both chronic iodine deficiency or iodine excess have been associated with hypertrophy and hyperplasia of follicular cells and the influence of thyroid hormone T3, T4 and thyrotropin TSH secretion. More frequent iodized salt consumption was associated with an increased risk of thyroid cancer, but this result was likely biased because local doctors had advised patients who had a goiter or thyroid cancer to consume iodized salt. The incidence of thyroid cancer has been rising steadily over the past few decades in most countries [ 1 ]. If several adjusted models were described, measures of association were extracted from the fully adjusted model. Zimmermann MB, Andersson M.

Although the data in Table 2 suggest that populations in areas of sufficient iodine intake seem to have fewer of the more aggressive ATC and FTC, but more PTC, the comparisons may have been biased by other factors that may influence the presentation of thyroid cancer besides iodine intake. Although iodine supplementation should be implemented to prevent and treat IDDs, iodine intake must be maintained at a safe level. Heavy metal toxicity and the environment. Access through your institution. Currently, the reports of iodine-induced hypothyroidism are not considered important.

Intravenous Methimazole in the Treatment of Refractory Hyperthyroidism. Hyperthyroidism and Thyrotoxicosis. Old Password. Comparing Cao county and Shan county, which are areas with high vlcc slimming products in malaysia iodine, to adequate iodine area such as in Mudan district, an increasing incidence is observed in in Mudan district. Lower prevalence of mild hyperthyroidism related to a higher iodine intake in the population: prospective study of a mandatory iodization programme. Value and pitfalls in iodine fortification and supplementation in the 21st century. Sustainable control of iodine deficiency in Iran: Beneficial results of the implementation of the mandatory law on salt iodization.

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Pharmacologically induced thyreopathy in patients with cardiovascular disease. Abstract We have critically reviewed the available information on iodine-induced hyperthyroidism IIH and epidemiology published sources and other reports as well as the experience hypothyrlidism the authors in Tasmania, Zaire, Zimbabwe, and Brazil. Abstract The aim of the study was to evaluate the correlation between thyroid cancer histotype and incidence rate IR and iodine nutrition level in two endemic goiter areas: the districts of Krakow and Nowy Sacz. Infection and Autoimmune Thyroid Disease. Iodine-Induced Thyroid Dysfunction. We have critically reviewed the available information on iodine-induced hyperthyroidism IIH from published sources and other reports as well as the experience of the authors in Tasmania, Zaire, Zimbabwe, and Brazil.

Most of them, however, are considered to be biased by either ethnic differences in the studies populations iodine induced hypothyroidism occurrence and epidemiology of cancer epidemiiology by environmental factors, other than iodine deficiency, that may also influence thyroid tumorigenesis, like exposure to radiation, goitrogens or diet. Providing cutting-edge scholarly communications to worldwide, enabling them to utilize available resources effectively. The quality of this study was judged to be medium. Niedziela M, Korman E Risk of neoplasm in autoimmune thyroid disease in children- transition from iodine deficiency to iodine sufficiency. Regarding the study quality of randomized trials, risk of bias was assessed according to the domains in the Cochrane Handbook for Systematic Reviews of Interventions as follows: 1 random sequence generation, 2 allocation concealment, 3 blinding of participants and personnel, 4 blinding of outcome assessment, 5 incomplete outcome data, and 6 selective reporting [ 17 ]. Truong, T.

When the mass of cells with such an occurrence and epidemiology becomes sufficient and iodine supply is increased, the subject may become thyrotoxic. Clinical hypothyrroidism arising from the increased intake of iodine in the Spanish population and the recommendation for systematic prescription of potassium iodide in pregnant and lactating women Consensus of the TDY Working Group of SEEN. Hyperthyroidism secondary to hysterosalpingography. Serum thyroglobulin as a biomarker of iodine deficiency in adult populations. Abstract We have critically reviewed the available information on iodine-induced hyperthyroidism IIH from published sources and other reports as well as the experience of the authors in Tasmania, Zaire, Zimbabwe, and Brazil.

If the address matches iodine induced hypothyroidism occurrence and epidemiology of cancer existing account you will receive an occurrencw with instructions to retrieve your username. Cerovskaand F. These changes may occur in localized foci within the gland or in the process of nodule formation. The risks of IIH are principally to the elderly who may have heart disease, and to those who live in regions where there is limited access to medical care. OKEN, R. More information is needed on the long-term health impact of IIH or "subclinical" IIH, especially in the course of prophylaxis programs with iodized salt or iodinated oil in regions where access to health care is limited. Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficienty or excess.

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The effect of excessive iodine intake on the thyroid gland of the rat. J Stat Theory Appl. Bondeson L, Ljungberg O. To study the effect of excess iodine and excess tyrosine on goiter in mice [28], high iodine feed high iodine and adequate tyrosine, HIAT could result in the typical colloid goiter in mice and the goiter rate was Williams, E.

The impact of geographical, clinical, dietary and radiation-induced features in epidemiology of thyroid cancer. The frequency of thyroid cancer epdemiology patients with cold nodules was 5. Thus, in this area ,more accumulated results are needed to be testable. Familial non-medullary thyroid carcinoma: an update. Tg is a KDa glycoprotein secreted into the lumen of follicles, whose tyrosyles serve as substrate for iodination and hormone formation. Over the past 25 years, universal salt iodization USI has been introduced in many countries as a safe, cost-effective and sustainable method to eliminate iodine deficiency disorders IDDsresulting in a greatly improved iodine status.

Also, its highly specific histological features are easy to recognize [ 97 ]. However, there was likely misclassification of exposure status as low-level iodine prophylaxis had been introduced in the formerly deficient areas before the study period. An alternative explanation for the observed increase in the number of papillary cancers could be the introduction and wider use of more modern and precise examination equipment through the years, as the reversal of iodine deficiency coincides with the dissemination of better techniques in the health system, including thyroid scintigraphy, ultrasound and fine-needle biopsy. Experimental studies have documented thyroid cancer induction by elevation of endogenous TSH, although in a small number of animals. Writing — original draft: RK.

Rights and permissions Reprints and Permissions. Chinese Journal of public health High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation. BMJ— View author publications. Pelizzo, M.

Management of the nontoxic multinodular goitre: A European questionnaire study. Thyroid Vol. To cite this article: J. Hypothyroisism PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China. Keep me logged in. Iodine Supplementation. Pharmacologically induced thyreopathy in patients with cardiovascular disease.

Relevância da ingestão de iodo como fator predisponente ao câncer de tireóide

National Toxicology Program. Current iodine nutrition status and progress toward elimination of iodine deficiency disorders in Jazan, Saudi Arabia. An assessment of iodine nutritional status and thyroid hormone levels in children aged 8—10 years living in Zhejiang Province, China: a cross-sectional study. BMC Women's Health Sub-group analyses are also required, including thyroid antibodies.

Disorders of the Thyroid Gland. TomimoriRosalinda Y. Monitoring the effects of iodine prophylaxis in the adult population of southern Italy with deficient and sufficient iodine intake levels: a cross-sectional, epidemiological study. Abstract We have critically reviewed the available information on iodine-induced hyperthyroidism IIH from published sources and other reports as well as the experience of the authors in Tasmania, Zaire, Zimbabwe, and Brazil. Request Username Can't sign in?

Patients developing AIT type I usually have a preexsiting nodular goiter. Tax calculation will be finalised during checkout. Fatourechi V. Endocrinol Metab Seoul. Cavaco, B.

Key points

Prevalence of hyperthyroidism according to type of vegetarian diet. Paroxysmal atrial fibrillation precipitated by amiodarone-induced thyrotoxicosis five months after cessation of therapy. Pharmacologically inducced thyreopathy in patients with cardiovascular disease. Breastfeeding and maternal and infant iodine nutrition. Clinical dilemmas arising from the increased intake of iodine in the Spanish population and the recommendation for systematic prescription of potassium iodide in pregnant and lactating women Consensus of the TDY Working Group of SEEN.

Thyroid Research 8: 8. Ajd J Cancer. Br J Cancer ; Iodine is required for the production of thyroid hormones. Iodine excess appears not to be an initiator, but may be a weak promoter. The UIC urinary iodine concentration in subjects from 29 rural areas were Table 1 Epidemiological criteria for assessment of iodine nutrition in populations based on median urinary iodine concentration [ 2324 ].

A critical review of food-associated factors proposed in the etiology of feline hyperthyroidism. LaurbergI. The WHO Global Database on iodine deficiency disorders: the importance of monitoring iodine nutrition. Thyrotoxicosis, Overview of Causes. Jessica FarebrotherMichael B.

Goiter is one of the main characteristics of iodine deficiency iodinne [ 4 ]. The characteristic feature of malignancy is an increased growth rate of the cell, and cancer development of a tumor can be thought of as a series of steps, each marked by the growth of a clone with higher growth rate than the rest of the lesion. Epidemiology of subtypes of hypothyroidism in Denmark. Factors controlling proliferation and differentiation of canine thyroid cells cultured in reduced severe conditions: effects of thyrotropin, cyclic AMP and growth factors.

Chin J Intern Med chinese Also, there is likely to be a latency period after exposure of susceptible individuals to iodine excess or deficiency and subsequent changes in the thyroid cancer incidence. All of the above reservations are probably reasons why comparison of thyroid carcinoma epidemiology in different populations and geographic areas are so difficult to perform and interpret, and why no specific solutions to the questions concerning environmental influence of iodine intake have been provided, despite a large number of studies over many years. Iodine-induced hyperthyroidism IIH has been frequently described when iodine is introduced into an iodine-deficient area [38], patients residing in iodine-sufficient areas [43]and iodinated preparation for water purification [40].

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Abstract The controversy that iodine intake may increase the risk of thyroid cancer has heightened over the past twenty years. Influence of iodization programmes on the epidemiology of nodular goitre. Thyroid hormones and antithyroid drugs. The Effects of Iodine Excess. Volume 8 Issue 1 Jan Tireotossicosi farmaco-indotta.

  • Alone, both iodine deficiency and excess increased the thyrocyte proliferation rate and induced thyroid adenomas, but induced no thyroid carcinomas.

  • Tireotossicosi farmaco-indotta.

  • Research on factors affecting children's iodine nutrition and thyroid goiter in iodine excessive region. Papers which showed both the percentage of subclinical hypothyroidism and median or mean urinary iodine concentration were included.

  • Download references. Circ J

  • We also excluded as an outlier a Finnish study that reported a prevalence of OTC of

Seasonal variation in plasma thyroid occurrenec concentrations in coastal versus inland populations of juvenile American alligators Alligator mississippiensis : Influence of plasma iodide concentrations. Iodine intake as a determinant of thyroid disorders in populations. A Hidden Solution. We have critically reviewed the available information on iodine-induced hyperthyroidism IIH from published sources and other reports as well as the experience of the authors in Tasmania, Zaire, Zimbabwe, and Brazil. OKEN, R.

Increase rates of the thyroid cancer are increasing after radiation exposure to I in children or adolescents. In the first cancrr conditions, elevated TSH results from chronic stimulation of the pituitary in response to a deficiency in the circulating levels of thyroid hormone. Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. Incidence rates newly diagnosed cases in a population over a given time period reveal patterns of disease by age, race, sex, ethnic group and geographic localization. Overweight, obesity, and cancer risk.

J Nutr. The mechanism by which an iodine excess induces thyroid diseases is not completely obvious. Kovacs et al. J Nutr.

Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficienty or excess. The WHO Global Database on iodine deficiency disorders: the importance of monitoring iodine nutrition. A Hidden Solution. View article.

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J Food Compos Anal. Stapleton, H. J Clin Endocrinol Metab. Endocrinology ; 7 Thyroid cancer and thyrotoxicosis in the United States: their relation to endemic goiter. After USI was started in moderate to severe iodine deficiency areas, the incidence of hyperthyroidism increased significantly.

  • Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood.

  • The risks of IIH are principally to the elderly who may have heart disease, and to those who live in regions where there is limited access to medical care. Close Figure Viewer.

  • Investigation on the iodine nutritional status and the prevalence of thyroid carcinoma in Zhoushan Archipelago residents. Hyperthyroidism was also observed on administration of 50 mg iodine in an elderly population with mild iodine deficiency at baseline [ 21 ].

  • Also, when the analysis was restricted to PTC, the authors found no significant association between fish intake and PTC risk.

  • Ichushi -Web and CiNii database were used for Japanese papers.

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Iodine Fortification and Hyperthyroidism. IIH is most commonly encountered in older persons with long standing nodular goiter and in regions of chronic iodine deficiency, but instances in the young have been recorded. Low dose oral iodized oil for control of iodine deficiency in children. Uncommon Causes of Thyrotoxicosis.

Subclinical Hyperthyroidism. Breastfeeding and maternal and infant iodine nutrition. The WHO Global Database on iodine deficiency disorders: the importance of monitoring iodine nutrition. Login to your account Username. IIH is most commonly encountered in older persons with long standing nodular goiter and in regions of chronic iodine deficiency, but instances in the young have been recorded. Salting-out homogeneous liquid-liquid microextraction for the spectrophotometric determination of iodate in food grade salt.

Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary iodin or excess. Effects iodine induced hypothyroidism occurrence and epidemiology of cancer potassium iodide in concentrations of TSH, tT 3 and tT 4 in serum of subjects with sporotrichosis. Iodine nutritional status after the implementation of the new iodized salt concentration standard in Zhejiang Province, China. Whole grain rice fortification as a solution to micronutrient deficiency: Technologies and need for more viable alternatives. Iodine status as determined by urinary iodine excretion in Lesotho two years after introducing legislation on universal salt iodization.

Thus, thyrocyte exposure to iodine in these cell studies was several orders of magnitude above that encountered under physiological conditions resulting from varying dietary iodine intakes. Br Med J 1: Interestingly, the high proliferation rates did not induce any malignant changes. Hiranuma, Y.

The controversy that iodine intake may increase the risk of thyroid cancer has heightened over the past twenty years. Iodine Epkdemiology and Hyperthyroidism. Abstract We have critically reviewed the available information on iodine-induced hyperthyroidism IIH from published sources and other reports as well as the experience of the authors in Tasmania, Zaire, Zimbabwe, and Brazil. Monitoring the effects of iodine prophylaxis in the adult population of southern Italy with deficient and sufficient iodine intake levels: a cross-sectional, epidemiological study. IIH may also occur with an increase in iodine intake in those whose hyperthyroidism Graves' disease is not expressed because of iodine deficiency. Forgot your password?

Sang et al. Postgrad Med J Studies from various laboratories using tritiated thymidine labeling, metaphase arrest techniques for mitotic index, or immunohistochemical decoration of statin a non-proliferation-specific nuclear antigen identifying quiescent G o -phase cells show that TSH stimulates, in a dose- and time-dependent way, the recruitment of noncycling G o cells into the cycling compartment, as well as entry into S-phase and the entry of G 2 cells into mitosis

Malignant disease of the thyroid gland and its relation to goiter in man and animals. It showed that the prevalence of hypothyroidism was an increasing trend, accompanied by iodine intake, and was 0. The other 11 cases were further reported [,]. Nippon Naibunpi Gakkai Zasshi Activity of antioxidant enzyme systems, including superoxide dismutase-3, are increased in iodine deficient rat thyroids, and this is accompanied by an increase of uracil and oxidized purine or pyrimidine adducts in thyroid DNA [ 48 ].

  • Another of these studies in pregnant women showed significantly higher values in the excess group than in the adequate group [ 66 ].

  • Since a rise in thyroid cancer IR was observed. Are cytologic and histopathologic features of hot thyroid nodules different from cold thyroid nodules?

  • A five-year follow-up study of goiter and thyroid nodules in three regions with different iodine intakes in China.

  • Laura Calvi and Gilbert H. Prevalence of hyperthyroidism according to type of vegetarian diet.

Thyrotoxicosis of other etiologies. Support Center Support Center. PubMed Google Scholar. Tumors: —]. Zablotska et al. After an iodine supplementation program, the incidence of papillary cancer rose and that of follicular cancer fell, but these trends were the same in both areas, and thus unrelated to the supplementation program Jpn J Clin Oncol.

J Physiol Pharmacol Nutr Cancer. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in Testing a tool for assessing the risk of bias for nonrandomized studies showed moderate reliability and promising validity.

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