Advertisement

Sign up for our daily newsletter

Advertisement

Myxedematous hypothyroidism and depression – Myxedema Coma: Diagnosis and Treatment

The participants were hypothyroid patients Female; Published : 07 September

Lucas Cox
Monday, October 8, 2018
Advertisement
  • Bladder dystonia and distension.

  • In fact, depression is the most common neuropsychiatric symptom in hypothyroidism [ 20 ].

  • Kirkegaard, A.

  • Your doctor will order other blood tests to get a thorough picture of your body systems. It seems, there is no correlation between the existence and severity of psychiatric symptoms and the degree of thyroid hormone abnormalities.

  • Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine.

MeSH terms

Thyroid peroxidase antibodies myxedematous hypothyroidism and depression gestation are a marker for subsequent depression postpartum. Recently, advances in biochemical, genetic, and neuroimaging fields have provided new insights into the thyroid-depression relationship. However, an attempt to decrease the incidence of postpartum depression in thyroid antibody positive women with daily administration of thyroxine for 18 weeks postpartum was unsuccessful [ 86 ]. Demartini, A. Hylander B, Rosenqvist U.

Patient Guide to Insulin The purpose of the Patient Guide to Insulin is to educate patients, parents, and caregivers about insulin treatment of diabetes. Navigate this Article. Whybrow, and A. View author publications. New England Journal of Medicine. A chemical pregnancy is an early pregnancy loss that occurs shortly after implantation. Some have reported diffuse global hypoperfusion [ 87 — 89 ] while others demonstrated decreased regional cerebral blood flow [ 90 — 92 ].

  • Accepted 26 Sep Campos-Barros, H.

  • Various factors could be behind this unusual state.

  • Williams, R.

  • Nasrin Rafee is an Internist. Tags: depression link research study.

  • However, parental T 3 is not only expensive and difficult to obtain, it may also contribute to increased mortality.

A form of decompensated hypothyroidism. Many patients in spite of being euthyroid myxedematous hypothyroidism and depression with symptoms such as sleep disorders, fatigue, and depression in particular [ 15 ]. Depression has been linked to various endogenous circadian rhythms abnormalities such as diurnal mood variation, abnormalities in core body temperature, cortisol secretion, and sleep-wake cycle [ 47 ]. Quijano-Vega says that the typical myxedema coma patient is usually an older woman with altered consciousness. Best Value!

Myxedema crisis is considered a medical emergency and requires immediate attention. Earn up to 6 CME credits per issue. Joffe RT, Singer W. European Journal of Endocrinology.

1. Introduction

In addition, depression is associated with changes in the HPT axis [ 21 ]. Full size image. To support a healthy thyroid in general, diet is important, according to Dr. Dayan CM, Panicker V.

TSH cut-off values based on depression was determined by Roc Curve analysis. The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain. Depression or Hypothyroidism. Case Presentation: An 85 year old man with a history of HCV, hypothyroidism on levothyroxine, and anemia presented with a 1 day history of total body pain. J Thyroid Res. In fact, several studies have confirmed the existence of classical feedback between the serotonergic and HPT systems. Patient Guides.

J Thyroid Res. This is also the time when women are either adn or they have gone through a menopause transition. Why are we talking about it in this article? Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. This information is not designed to replace a physician's independent judgment about the appropriateness or risks of a procedure for a given patient. Depression is more prevalent than we think.

Historical Features

Get our free guide when you sign up for our newsletter. To the best of our knowledge, this is the first study to focus on TSH cut-off point for depression. The end stage of Hashimoto's thyroiditis results in hypothyroidism. Thyroid dysfunction in major psychiatric disorders in a hospital based sample.

Special Issues. NR is responsible for the data collection, design of the study and performing BDI questionnaire review and supervising the patients. Afsaneh Talaei is a professor of Endocrinology. Received 25 Jul

However, the vast majority of myxedematous hypothyroidism and depression with depression do not have myedematous evidence of thyroid dysfunction [ 2122 ]. Therefore, depressed patients with genetically determined lower T4 to T3 conversion could therefore derive more benefit from thyroid hormone augmentation therapy [ 70 ]. These compounds attract water, which lead to swelling. Bailey et al. Myxedema Coma: Diagnosis and Treatment.

Many patients in myxedematous hypothyroidism and depression of being euthyroid present with symptoms such as sleep disorders, fatigue, and depression in particular [ 15 ]. Thyroid and bipolar disorder Thyroid and bipolar disorder. Psychiatric manifestations as the only clinical sign of hypothyroidism. Carle A. Also, an NLR of 0. Evidence points to normalization of pretreatment thyroid function tests, primarily T4 levels, with remission of depression. General information.

Background

This can have a negative impact on nearly all bodily processes and body systems. Brain glucose metabolism in hypothyroidism: a positron emission tomography study before and after thyroid hormone replacement therapy. Rapid cycling bipolar affective disorder.

The diagnostic dilemma of myxedema and madness, axis I and II. Both hypothyroidism and depression are common conditions and they have numerous things in common. As with all other manifestations of hypothyroidism, treatment is with thyroid replacement therapy, titrated to TSH. Received : 19 October

Acknowledgements The authors would like to gratefully acknowledge the Arak University of Medical Sciences because the study was funded by the university. TSH cut-off points were determined to be 3. Alex, S. Introduction The association between thyroid function and psychiatric disorders particularly mood disorders has long been recognized.

Journal of Thyroid Research

This could also indicate a stronger relationship between two conditions which will be discussed below. Complications of Hypothyroidism. Hypothyroid patients frequently experience problems such as apathy, depression, psychomotor slowing, and cognitive dysfunction. Both hypothyroidism and depression are common conditions and they have numerous things in common.

Competing interests The authors declare that there is no conflict of interest regarding the Publication of this article. An absent Tests for nocturnal surge [ 48 ] has been noted in depression and a lower basal TSH has been reported in major depression as opposed to nonmajor depression [ 49 ]. In addition, depression is associated with changes in the HPT axis [ 21 ]. Decompensation into myxedema coma occurs when the hypothyroid patient's homeostatic mechanisms are disrupted. Acta Medica Austriaca.

ALSO READ: Images Hypothyroidism Pictures Gigantism

Many patients in spite of being euthyroid present with symptoms such biol 1001 tests for hypothyroidism sleep disorders, fatigue, and depression in particular [ 15 ]. The involvement of hypothalamic-pituitary-thyroid HPT axis in the pathogenesis of depression is supported by various studies. In addition, myxedematous coma, particularly in elderly hypothyroid patients, can be precipitated by central nervous system depressants, infection, and possibly stressful dental procedures. Zoeller RT, Rovet J. Levitt, M. Accepted : 22 August Hypothyroidism often misdiagnosed as psychiatric illness.

Myxedema megacolon—late. Furthermore, Bauer et al. Nevertheless, therapy with levothyroxine alone was not sufficient to induce a total remission of depressive symptoms in this population [ 13 ]. Therefore, it is important to consider various factors in determining a TSH cut-off value.

Biol 1001 tests for hypothyroidism, these foods are very popular, and they include spinach, soybeans, strawberries, sweet potatoes, broccoli, and Brussels sprouts, among others. A study of correlation between depression and hypothyroidism in female patients. The authors would like to gratefully acknowledge the Arak University of Medical Sciences because the study was funded by the university. Indian J Endocrinol Metab.

Background

Psychiatric symptoms in endocrine diseases. Myxedema crisis is a medical emergency. First direct evidence of cerebral metabolic effects of hypothyroidism on an adult brain. What are the symptoms of myxedema crisis? Studies show that subjects on thyroxine have poorer psychological wellbeing than their healthy counterparts with no thyroid diseases and it only confirms the relationship between hypothyroidism and depression.

Both excess and insufficient thyroid hormones can cause mood abnormalities including depression that is generally reversible with adequate thyroid treatment. Purchase Access: See My Options close. British Journal of Psychiatry. Hypothyroidism and depression are similar in terms of clinical features. Med Clin North Am. Nevertheless, therapy with levothyroxine alone was not sufficient to induce a total remission of depressive symptoms in this population [ 13 ].

An accurate diagnosis generally follows a careful history, physical examination and laboratory evaluation. Myxedema crisis often myxedematous hypothyroidism and depression after a long history of hypothyroidism. On the other hand, most of the patients with primary depression have normal myxedemaotus function. A reappraisal using objective psychological measurement. Effect of Depression Treatment on Thyroid Status Normalization of pretreatment thyroid function tests mainly T4 levels with remission of depression has been reported [ 7576 ]. Understanding the link between both disorders will guide clinicians to appropriately interpret thyroid function tests in depression, better understand the pathophysiology of both diseases, and try to identify the subjects who will benefit the most from thyroid supplementation.

And depression are the symptoms of myxedema? The effects myxedeematous thyroid state on beta-adrenergic and serotonergic receptors in rat brain. Also, the findings showed that a TSH cut-off point of 2. He was unable to further characterize the pain. This can have a negative impact on nearly all bodily processes and body systems.

Epidemiology

In fact, the degree of T3 reduction is associated with severity of depression. Peer Review reports. Explains what nerves are affected in each type of diabetic neuropathy.

Based on this questionnaire, scores below 10 were considered as normal, while scores above 10 were indicative of depression. Researchers have long recognized that there is a and depression between thyroid function and depression, although the exact mechanisms of how they interact are not fully understood. It seems that there are analogous mechanisms leading to the similarity of symptoms in hypothyroidism and depression [ 19 ]. The hypothalamic-pituitary-thyroid axis. To the best of our knowledge, this is the first study to focus on TSH cut-off point for depression. Consent for publication Not applicable. The end stage of Hashimoto's thyroiditis results in hypothyroidism.

  • Without a rapid diagnosis, myxedema crisis is often fatal.

  • Even worse than the above symptoms? Received : 19 October

  • Effects of thyrotropin-releasing hormone in depression. One preeminent hypothesis to explain the above finding is that chronic TRH hypersecretion associated with depression leads to downregulation of pituitary TRH receptors [ 24535556 ].

  • This study was conducted in accordance with the Declaration of Helsinki.

  • Furthermore, thyroid hormones are reported by many authors to be an effective adjunct treatment for depression.

Med Clin North Am. This is an open access article distributed under the Creative Commons Attribution License, which permits and depression use, distribution, and reproduction in any medium, provided the original work is properly cited. Mirella P. Deiodination occurs intracellularly mainly in glial cells and T4 must enter these cells through specialized plasma membrane carrier proteins including organic anion transporter polypeptide 1 OATP1C1 and monocarboxylase transporter 8 MCT8. Galinowskia et al. The extent to which the endogenous TRH system is involved in mood regulation and the underlying implicated mechanisms remain to be defined.

The most concerning finding was that gender differences in hypothyroidizm prevalence of depression were already present at age 12 and hormonal changes may have something to do with it [iv]. Sign up for our myxedematous hypothyroidism and, and get this free sanity-saving guide to life in the time of corona. Myxedema crisis is a medical emergency. If the thyroid gland is unable to produce thyroid hormone, TSH will continue to be produced in an attempt to prod the thyroid gland into production. Clin Endocrinol. For some people, treating the underlying thyroid imbalance can relieve depression. The case of a young woman who was treated one and one half years with psychopharmacologic agents and psychotherapy until hypothyroidism was diagnosed.

What you should know

False Lab Results—Psychiatric or Thyroid? Home » Thyroid » Hypothyroidism and Depression Connection. Symptoms of hypothyroidism underactive thyroid can disrupt several parts of your life.

  • A possible explanation would be a greater inactivation of T4 to rT3 in depressed patients compared to healthy subjects [ 74 ].

  • Your doctor will order other blood tests to get a thorough picture of your body systems. Rates of depression could be even higher than estimates show.

  • Nevertheless, therapy with levothyroxine alone was not sufficient to induce a total remission of depressive symptoms in this population [ 13 ].

  • To cite this abstract:.

  • Armour Thyroid Side Effects.

  • Myxedema coma is a rare and potentially fatal complication of hypothyroidism. Thyrotropin-releasing hormone TRH is constantly inhibited by serotonin.

Thyroid hormone is important for cell metabolism. This information is not designed to replace a physician's independent judgment myxedematouw the appropriateness or risks of a myxedematous hypothyroidism and depression for a given patient. How is myxedema diagnosed? This neurotransmitter also has an inhibitory impact on TRH secretion, thus suggesting the potential existence of a feedback loop which allows activation of HPT axis when levels of serotonin are low [xi]. J Clin Endocrinol Metab. Researchers have long recognized that there is a link between thyroid function and depression, although the exact mechanisms of how they interact are not fully understood.

ALSO READ: Full Feeling In Throat Hypothyroidism

Hypothyroid patients frequently depression problems such as apathy, depression, psychomotor slowing, and cognitive dysfunction. Your doctor will order other blood tests to get a deprsssion picture of your body systems. A chemical pregnancy is an early pregnancy loss that occurs shortly after implantation. Problems with this gland, however, can result in a thyroid imbalance that can affect the body in various ways. The involvement of hypothalamic-pituitary-thyroid HPT axis in the pathogenesis of depression is supported by various studies. We may receive a paid commission or other income on certain products. Zoeller RT, Rovet J.

Treatment with pychotrophic agents for symptomatic relief of psychiatric complaints should be undertaken with great caution in patients with endocrine disorders. Quijano-Vega says that the condition itself is uncommon. Blood tests can help your doctor confirm this. Santin A.

Clinical Nuclear Medicine. This could result from a defect in the thyroid myxedemayous receptor [ 26 ], or in the thyroid hormone transport and uptake into the brain and neuronal cells [ 727 ]. Jinnouchi, R. Hypothyroidism and depression are similar in terms of clinical features. The Lancet. Both excess and insufficient thyroid hormones can cause mood abnormalities including depression that is generally reversible with adequate thyroid treatment. Google Scholar.

More recently, studies assessing hypothyroisism newer and more tolerable antidepressant agents, the selective serotonin reuptake inhibitors SSRIs in combination with T3 have yielded confounding results. Larsen, J. Behavioural Brain Research. These levels have been found to regress after successful treatment of depression [ 32 ]. AC contributed to the designing and manuscript preparation.

A study of correlation between depression and hypothyroidism in female and depression. To the best of our knowledge, this is the first study to focus on TSH cut-off point for depression. Both depression and hypothyroidism are common, particularly in older women, and there is a reasonable prevalence of overlap of two conditions. The presence of antithyroid antibodies in patients with affective and nonaffective psychiatric disorders. Thyroid Today.

Elevated transaminases. Iacovides, P. Of course there are some limitations due to small sample size, convenience recruitment and also the population of the study was not large enough to provide the statistical power to analyze the effects of sex or age and there is the need for broad based studies. Read the full article. However, a low level of serum T 4 and T 3 with a normal TSH level may simply indicate that the patient's thyroid function tests have been altered as a result of illness unrelated to the thyroid euthyroid sick syndrome. Thyroid Cancer Guide.

More recently, a higher frequency of mild to moderate depression was observed in postpartum female subjects with positive antithyroid hpothyroidism regardless of thyroid function [ 83 — 85 ]. AORN J. Forchetti, G. However, the authors suggested that T3 and SSRI cotherapy may be effective in a subset of depressed patients including those with atypical depression, or those with functional D1 gene polymorphism [ 69 ].

Acta Endocrinologica. Abstract The relation between myxedemstous function and depression has long been recognized. Canadian Journal of Psychiatry. However, the use of thyroid hormones as an adjunct therapy to antidepressants in the absence of subclinical or clinical hypothyroidism should be further investigated. It can also develop when someone stops taking their thyroid medication. The term myxedema is often used interchangeably with hypothyroidism and myxedema coma.

  • The present results could provide a depression-specific cut-off point for TSH, which may help improve patient care. This is a life-threatening state that requires immediate medical attention.

  • Kirkegaard C, Faber J. It was concluded that LHb could mediate the effect of thyroid system on serotonin function in DRN [ 23 ].

  • Revista Brasileira de Psiquiatria. Individuals who had developed euthyroid state under treatment with levothyroxine with TSH levels of 0.

  • For some people, treating the underlying thyroid imbalance can relieve depression.

J Endocrinol Invest. Unfortunately, these foods are very popular, and they include spinach, soybeans, strawberries, sweet potatoes, broccoli, and Brussels sprouts, among others. Decompensation into myxedema coma occurs when the hypothyroid patient's homeostatic mechanisms are disrupted. Even with early detection and appropriate treatment, mortality ranges from 30 to 60 percent. As mentioned earlier, no TSH reference range can fit all ages, races, or sexes.

On the other hand, reduced intracerebral serotonin concentration in depression could lead to increased TRH concentration in brain tissues. Read the winning articles. Suzuki T, Abe T. Also, the severity of depression symptoms was found to be correlated with the level of serum thyroid stimulating hormone TSH.

Patients with hypothyroidism typically have a history of fatigue, weight gain, constipation and cold intolerance. Thyroid function and the natural history of depression: findings from the Caerphilly Prospective Study CaPS and a meta-analysis. Academic Editor: Michael Bauer.

What Is Dopamine? The presence of potentially irreversible cognitive deterioration, as well as the inocuity and sensibility of thyroid hormones examination justify the systematic thyroid evaluation for all myxedematous hypothyroidism psychiatric patients. They are vepression prevalent in women, especially during menopause time, and they share some symptoms. Efficacy of T3 This meta-analysis supports the efficacy of T3 in accelerating clinical response to tricyclic antidepressants in patients with nonrefractory depression. Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients. Patients with thyroiditis may have a short period of being hyperthyroid and it may be best to avoid routine dental treatment during that period. People develop depression due to all sorts of reasons.

Depression, C. BMC Psychiatry 17, A meta-analysis of these early double-blind placebo controlled trials concluded that Deression was effective in accelerating the clinical response to tricyclic antidepressants in patients with nonrefractory depression. Physicians should also be alert to the possibility of depression in the seemingly demented patient and perform depression screening in any patient with mental status changes. This Patients' Guide will help you eat well all day long with our easy diabetic recipes.

What you should know

A CT scan of your brain will likely be needed as well. Clin Biochem. Van Son, and V. Generalized swelling.

  • Deiodination occurs intracellularly mainly in glial cells and T4 must enter these cells through specialized plasma membrane carrier proteins including organic anion transporter polypeptide 1 OATP1C1 and monocarboxylase transporter 8 MCT8. Jackson IMD.

  • In addition, myxedematous coma, particularly in elderly hypothyroid patients, can be precipitated by central nervous system depressants, infection, and possibly stressful dental procedures.

  • One preeminent hypothesis to explain the above finding is that chronic TRH hypersecretion associated with depression leads to downregulation of pituitary TRH receptors [ 24535556 ].

  • Kicey CA. Endocrinol Metab Clin North Am.

Herbert et al. The mechanisms underlying the interaction between thyroid function and depression remain to be clarified and a causal relationship between the two cannot be established yet. The patients were evaluated in terms of depression by BDI. Neuropsychiatric Manifestations of Thyroid Disorders Primary thyroid disorders including both hypothyroidism and hyperthyroidism may be accompanied by various neuropsychiatric manifestations ranging from mild depression and anxiety to overt psychosis.

According to the literature, Endocr Res. Neurodevelopmental and neurophysiological actions of thyroid hormone. Thyrotropin-releasing hormone TRH is constantly inhibited by serotonin.

The thyrotropin response to thyrotropin-releasing hormone in endogenous depression. Hypothyroidism will present with a high TSH and a low serum free T4 level. Stula et al. Recently, advances in biochemical, genetic, and neuroimaging fields have provided new insights into the thyroid-depression relationship.

This test measures the level of T4, a hormone produced directly by your thyroid. Myxedematous hypothyroidism and depression W. The dentist by detecting the early signs and symptoms of hypothyroidism and thyroiditis can refer the patient for medical diagnosis and treatment and avoid potential complications of treating patients with uncontrolled disease. Resources Community Advice Patient Guides.

  • A full list of foods to support thyroid function can be found here.

  • Journal of Affective Disorders Mar; Long-standing changes in thyroid function lead to considerable changes in dynamics of the cerebral circulation and these, rather than direct effects of the hormone in the brain, may be responsible for symptoms of brain dysfunction.

  • Fewer studies assessed the efficacy of T4 in the treatment of affective disorders. Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy.

  • Thyroid medications are sometimes combined with antidepressants to treat depression in people with normal thyroid functioning.

Kinuya, T. Myxedematous hypothyroidism and depression, and O. Postpartum thyroid dysfunction and depression in an dwpression population. Thyroid hormones have been used as an adjunct to antidepressant therapy since the late s to accelerate clinical response to antidepressants acceleration and to potentiate clinical response in non-responders to antidepressants augmentation. American association of clinical endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism.

ALSO READ: Hypothyroidism Treatment Armour Vs Synthroid

Patient Guide to Osteoporosis Prevention If you are like many people, you myxedematous hypothyroidism and depression think that osteoporosis—a condition marked by low bone mineral density, which leads to lowered bone strength and a heightened risk of fractures—is something you will not have to worry about until later in life. In addition, myxedematous coma, particularly in elderly hypothyroid patients, can be precipitated by central nervous system depressants, infection, and possibly stressful dental procedures. By reading this information-only website, you take full responsibility for what you choose to do with this website's information or outcomes. This is a life-threatening state that requires immediate medical attention. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Evidence points to normalization of pretreatment thyroid function tests, primarily T4 levels, with remission depreszion depression. Thyroid hormones play a significant role in brain development. Psychiatric symptoms usually resolve within 1 week, and may be hastened with the addition of antipsychotics, though some patients report that that a complete return to baseline may take months. Hypothalamic-pituitary-thyroid axis in depression. These thyroid medications can either reduce the body's production of thyroid hormones or replace the missing hormones to help improve both thyroid functioning and mood. Article PubMed Google Scholar

This cross-sectional study was performed on hypothyroid patients, aged 19—68 years. Psychoneuroendocinology of mood disorders. To support a healthy thyroid in general, diet is important, according to Dr.

Although many studies inspected the relationship between depression and thyroid hormones, this subject is still poorly elucidated. J Clin Mycedematous Metab. Psychological Medicine Oc Taking Antidepressants During Pregnancy. Thyroid hormone and bipolar patients A world-renowned expert on bipolar disorder discusses the latest research demonstrating that thyroid hormone can have a positive and profound effect on mood in bipolar patients.

Treatment for hypothyroidism involves taking a synthetic version of the T4 hormone known as levothyroxine Levothroid, Levoxyl. The 5-HT deficiency theory of depression. Quijano-Vega says that biol 1001 tests for hypothyroidism typical myxedema coma patient is usually an older woman with altered consciousness. Part II of the series on thyroid disorders discusses hypothyroidism and thyroiditis that may be found in dental patients. Journal of Clinical Endocrinology and Metabolism Feb. When it comes to T4, results are still contradictory due to a diversity of factors such as differences in phenotypes of depressive patients, severity and duration of disease, and many others [x].

Mental changes accompanying thyroid gland dysfunction. Pontiroli, and O. Arterial blood gases often reveal respiratory acidosis, hypoxia and hypercapnia. More related articles. Triiodothyronine augmentation in the treatment of refractory depression: a meta-analysis.

De Carvalho G. Once T4 hormone levels are restored, symptoms become more manageable, though this may take several weeks. As demonstrated above, depression and hypothyroidism are connected in many ways, but it is a little-known fact that they have some other things in common. American Thyroid Association. Normally, the thyroid regulates various functions by releasing steady levels of thyroid hormones.

Scarone, A. Kastin, R. You should also know that hypothyroiism taking a daily pill prescribed by your doctor, you can work towards maintaining healthy thyroid hormone levels. Lateral habenula as a link between thyroid and serotoninergic system modiates depressive symptoms in hypothyroidism rats. Arato, and C. Abdominal distension. In patients treated with T4, psychological symptoms may persist even when they achieve a euthyroid state [ 16 ].

Brain blood flow changes in depressed patients treated with interpersonal psychotherapy or venlafaxine hydrochloride: preliminary findings. Myxedema Coma: Diagnosis and Treatment. View at: Google Scholar I. Recently, advances in biochemical, genetic, and neuroimaging fields have provided new insights into the thyroid-depression relationship. Read the Issue.

Ruth, a year-old woman who has lived with hypothyroidism for more than decade, was hospitalized and diagnosed with myxedema coma after not taking her thyroid medication for six weeks. Background Thyroid hormones play a significant role in brain development. Complications of Hypothyroidism. Cite this article Talaei, A. Any and all trademarks, logos brand names and service marks displayed on this website are the registered or unregistered Trademarks of their respective owners.

Sidebar1?
Sidebar2?